Evidence map›Paper›PMID 30996129›Full record

ArticleAging2019

The acute transcriptional response to resistance exercise: impact of age and contraction mode.

Colleen S Deane, Ryan M Ames, Bethan E Phillips, Michael N Weedon, Craig R G Willis, Catherine Boereboom, Haitham Abdulla, Syed S I Bukhari, Jonathan N Lund, John P Williams and 7 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07018843 (Metabolic Characterisation of Critically Ill Patients), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07018843 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Metabolic Characterisation of Critically Ill Patients: An Observational Study Focusing on Mitochondria

TypeobservationalSponsorUniversity Hospital Southampton NHS Foundation TrustRan2025 to 2026Enrolled20ConditionsCritical Illness
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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  8. Association between age and muscle function, architecture, and composition in long-distance master runners: a cross-sectional study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Colleen S Deane *Department of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, UK.
Ryan M Ames *Living Systems Institute, University of Exeter, Exeter EX4 4QD, UK.
Bethan E PhillipsMRC-ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
Michael N WeedonGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Craig R G WillisDepartment of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, UK.
Catherine BoereboomMRC-ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
Haitham AbdullaMRC-ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
Syed S I BukhariMRC-ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
Jonathan N LundDepartment of Surgery, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
John P WilliamsMRC-ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
Daniel J WilkinsonMRC-ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
Kenneth SmithMRC-ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
Iain J GallagherFaculty of Health Sciences and Sport, University of Stirling, Stirling FK9 4LA, UK.
Fawzi KadiSchool of Health Sciences, Örebro University, Örebro 70182, Sweden.
Nathaniel J SzewczykMRC-ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
Philip J AthertonMRC-ARUK Centre of Research Excellence and National Institute of Health Research, Biomedical Research Centre, Postgraduate Entry Medical School, Royal Derby Hospital Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
Timothy EtheridgeDepartment of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, UK.
University of Exeter · GBRoyal Derby Hospital · GBNottingham Biomedical Research Centre · GBUniversity of Nottingham · GBÖrebro University · SEUniversity of Stirling · GB

Funding

Arthritis Research UK 19891Biotechnology and Biological Sciences Research Council BB/J014400/1Biotechnology and Biological Sciences Research Council BB/M009122/1Biotechnology and Biological Sciences Research Council BB/N015894/1Medical Research Council MR/K00414X/1Medical Research Council MR/P021220/1Wellcome Trust WT105618MA
6 · The paper itself

Abstract

Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and age, are poorly defined. We used transcriptomics to compare age-related molecular responses to acute CON and ECC exercise. Eight young (21±1 y) and eight older (70±1 y) exercise-naïve male volunteers had

Indexed as

AgedAgingDown-RegulationGene OntologyHealthy VolunteersHumansMaleMuscle ContractionMuscle, SkeletalResistance TrainingRNA-SeqTranscriptomeUp-RegulationYoung Adultconcentriceccentricsarcopeniatranscriptome

Identifiers

PMID30996129
PMCPMC6503873
OpenAlexW2939978146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.