Evidence map›Paper›PMID 30996101›Full record

ArticleJournal of virology2019

Comparisons of Human Immunodeficiency Virus Type 1 Envelope Variants in Blood and Genital Fluids near the Time of Male-to-Female Transmission.

Corey A Williams-Wietzikoski, Mary S Campbell, Rachel Payant, Airin Lam, Hong Zhao, Hannah Huang, Anna Wald, Wendy Stevens, Glenda Gray, Carey Farquhar and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Corey A Williams-WietzikoskiCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Mary S CampbellDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Rachel PayantCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Airin LamDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Hong ZhaoDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Hannah HuangCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Anna WaldDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Wendy StevensDepartment of Molecular Medicine and Haematology, University of Witwatersrand, Johannesburg, South Africa.
Glenda GrayPerinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Carey FarquharDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Helen ReesReproductive Health & HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Connie CelumDepartment of Medicine, University of Washington, Seattle, Washington, USA.
James I MullinsDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Jairam R LingappaDepartment of Medicine, University of Washington, Seattle, Washington, USA lingappa@uw.edu lfrenkel@uw.edu.
Lisa M FrenkelCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA lingappa@uw.edu lfrenkel@uw.edu.
University of Washington · USInfectious Disease Research Institute · USUniversity of the Witwatersrand · ZA

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9M
Viral Determinants of HIV-1 Transmission in African HeterosexualsP01AI057005 · NIAID · UNIVERSITY OF WASHINGTON · PI COREY, LAWRENCE · 2003 to 2014
$20.5M
Mucosal Transmission and Localized Superinfection in HIV-1K08AI074424 · NIAID · UNIVERSITY OF WASHINGTON · PI CAMPBELL, MARY S · 2007 to 2011
$603k
NIAID NIH HHS K08 AI074424NIAID NIH HHS P01 AI057005NIAID NIH HHS P30 AI027757
6 · The paper itself

Abstract

To better understand the transmission of human immunodeficiency virus type 1 (HIV-1), the genetic characteristics of blood and genital viruses from males were compared to those of the imputed founding virus population in their female partners. Initially serodiscordant heterosexual African couples with sequence-confirmed male-to-female HIV-1 transmission and blood and genital specimens collected near the time of transmission were studied. Single viral templates from blood plasma and genital tract RNA and DNA were sequenced across HIV-1

Indexed as

AdultFemaleGenitaliaHeterosexualityHIV-1HIV Envelope Protein gp160HIV InfectionsHumansMalePhylogenyReceptors, CCR5Receptors, CXCR4RNA, ViralSemenSequence AnalysisYoung AdultCCR5 protein, humanCXCR4 protein, humangp160 protein, Human immunodeficiency virus 1HIV Envelope Protein gp160Receptors, CCR5Receptors, CXCR4RNA, Viralcoreceptor usagegenetic bottleneckheterosexual transmissionHIVN-linked glycosylationviral compartmentalization

Identifiers

PMID30996101
PMCPMC6580966
OpenAlexW2937679666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.