ArticleBreast cancer research : BCR2019
Association between prediagnostic leukocyte telomere length and breast cancer risk: the Singapore Chinese Health Study.
Article in Breast cancer research : BCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis.Exploration of targeted anti-tumor therapy · 2025Pooled it
- Trial
- Melatonin and Breast Cancer: A Review Article.Chonnam medical journal · 2025Review
- Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics.Experimental hematology & oncology · 2025Review
- Impact of khat (Catha edulis) and oral contraceptive use on telomerase levels and tumor suppressor genes p53 and p21 in normal subjects and breast cancer patients.Scientific reports · 2024Article
- Higher peripheral blood mitochondrial DNA copy number and relative telomere length in under 48 years Indonesian breast cancer patients.BMC research notes · 2024Article
- Role of telomere length in human carcinogenesis (Review).International journal of oncology · 2023Review
- The association between sleep quality and telomere length: A systematic literature review.Brain, behavior, & immunity - health · 2023Review
- The causal relationship between genetically determined telomere length and meningiomas risk.Frontiers in neurology · 2023Article
- Triclosan is associated with breast cancer via oxidative stress and relative telomere length.Frontiers in public health · 2023Article
- Relationship between genetically determined telomere length and glioma risk.Neuro-oncology · 2022Article
- Relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: A Mendelian randomization study.Frontiers in oncology · 2022Article
- RecQ Helicase Somatic Alterations in Cancer.Frontiers in molecular biosciences · 2022Review
- Identification of Prognostic and Tumor Microenvironment by Shelterin Complex-Related Signatures in Oral Squamous Cell Carcinoma.Oxidative medicine and cellular longevity · 2022Article
- Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco.Environmental health : a global access science source · 2021Article
- Shorter Leukocyte Telomere Length Is Associated with Worse Survival of Patients with Bladder Cancer and Renal Cell Carcinoma.Cancers · 2021Article
- Article
- Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population.Communications biology · 2021Article
- Leukocyte telomere length, cancer incidence and all-cause mortality among Chinese adults: Singapore Chinese Health Study.International journal of cancer · 2021Article
- Analysis of the autoimmune regulator (AIRE) gene variant rs2075876 (G/A) association with breast cancer susceptibility.Journal of clinical laboratory analysis · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTelomeres and telomerase play key roles in the chromosomal maintenance and stability. Recent epidemiological studies have shown that longer telomeres are associated with increased risk of several cancer types. However, epidemiological data for telomere length and risk of breast cancer are sparse.
methodsWe prospectively studied the association between telomere length and risk of breast cancer in 14,305 middle-aged or older Chinese women of the Singapore Chinese Health Study including 442 incident breast cancer cases after 12.3 years of follow-up. Relative telomere length in peripheral blood leukocytes was quantified using a validated monochrome multiple quantitative polymerase chain reaction method. The Cox proportional hazard regression method was used to estimate hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) for breast cancer associated with longer telomeres after adjustment for potential confounders.
resultsLonger telomeres were significantly associated with higher risk of breast cancer in a dose-dependent manner (P
conclusionsThe findings of the present study support the hypothesis that longer telomeres may be a risk factor for breast cancer. Telomere length in peripheral blood leukocytes may be developed as a biomarker for breast cancer risk prediction.
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