Evidence map›Paper›PMID 30995824›Full record

Trial reportNutrients2019

Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study.

Claire S Byrne, Edward S Chambers, Tom Preston, Catriona Tedford, Jerusa Brignardello, Isabel Garcia-Perez, Elaine Holmes, Gareth A Wallis, Douglas J Morrison, Gary S Frost

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  17. Gut microbiota in overweight and obesity: crosstalk with adipose tissue.Nature reviews. Gastroenterology & hepatology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Claire S ByrneSection for Nutrition Research, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK. claire.byrne@imperial.ac.uk.ORCID 0000-0001-7578-6237
Edward S ChambersSection for Nutrition Research, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK. e.chambers@imperial.ac.uk.
Tom PrestonStable Isotope Biochemistry Laboratory, Scottish Universities Environmental Research Centre, University of Glasgow, East Kilbride, Glasgow G75 0QF, Scotland. Tom.Preston@glasgow.ac.uk.
Catriona TedfordSchool of Computing, Engineering and Physical Sciences, University of the West of Scotland, Paisley Campus, Paisley PA1 2BE, Scotland. Catriona.Tedford@uws.ac.uk.ORCID 0000-0002-3246-9933
Jerusa BrignardelloDepartment of Surgery and Cancer, Computational and Systems Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. j.brignardello-guerra15@imperial.ac.uk.
Isabel Garcia-PerezDepartment of Surgery and Cancer, Computational and Systems Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. i.garcia-perez@imperial.ac.uk.
Elaine HolmesDepartment of Surgery and Cancer, Computational and Systems Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. elaine.holmes@imperial.ac.uk.
Gareth A WallisSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. g.a.wallis@bham.ac.uk.ORCID 0000-0002-1400-0859
Douglas J MorrisonStable Isotope Biochemistry Laboratory, Scottish Universities Environmental Research Centre, University of Glasgow, East Kilbride, Glasgow G75 0QF, Scotland. Douglas.Morrison@glasgow.ac.uk.ORCID 0000-0002-4161-5699
Gary S FrostSection for Nutrition Research, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK. g.frost@imperial.ac.uk.
Hammersmith Hospital · GBImperial College London · GBScottish Universities Environmental Research Centre · GBMurdoch University · AUUniversity of Birmingham · GBUniversity of the West of Scotland · GB

Funding

Biotechnology and Biological Sciences Research Council BB/H004971/1Biotechnology and Biological Sciences Research Council BB/L004259/1
6 · The paper itself

Abstract

Supplementation with inulin-propionate ester (IPE), which delivers propionate to the colon, suppresses ad libitum energy intake and stimulates the release of satiety hormones acutely in humans, and prevents weight gain. In order to determine whether IPE remains effective when incorporated into food products (FP), IPE needs to be added to a widely accepted food system. A bread roll and fruit smoothie were produced. Twenty-one healthy overweight and obese humans participated. Participants attended an acclimatisation visit and a control visit where they consumed un-supplemented food products (FP). Participants then consumed supplemented-FP, containing 10 g/d inulin or IPE for six days followed by a post-supplementation visit in a randomised crossover design. On study visits, supplemented-FP were consumed for the seventh time and ad libitum energy intake was assessed 420 min later. Blood samples were collected to assess hormones and metabolites. Resting energy expenditure (REE) was measured using indirect calorimetry. Taste and appearance ratings were similar between FP. Ad libitum energy intake was significantly different between treatments, due to a decreased intake following IPE-FP. These observations were not related to changes in blood hormones and metabolites. There was an increase in REE following IPE-FP. However, this effect was lost after correcting for changes in fat free mass. Our results suggest that IPE suppresses appetite and may alter REE following its incorporation into palatable food products.

Indexed as

Dietary SupplementsFood HandlingObesityAnti-Obesity AgentsAppetiteBasal MetabolismCalorimetry, IndirectColonCross-Over StudiesDouble-Blind MethodEnergy IntakeFemaleHormonesHumansInulinMaleAnti-Obesity AgentsHormonesInulinPropionatespropionic acidappetiteenergy expenditureenergy intakepropionateSCFA

Identifiers

PMID30995824
PMCPMC6520886
OpenAlexW2939108273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.