Evidence map›Paper›PMID 30995819›Full record

ArticleJournal of clinical medicine2019

Serum Erythroferrone Levels Associate with Mortality and Cardiovascular Events in Hemodialysis and in CKD Patients: A Two Cohorts Study.

Belinda Spoto, Rahul Kakkar, Larry Lo, Matt Devalaraja, Patrizia Pizzini, Claudia Torino, Daniela Leonardis, Sebastiano Cutrupi, Giovanni Tripepi, Francesca Mallamaci and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Observational
  13. Review
  14. Article
  15. Article
  16. Review
  17. New diagnostic tools for delineating iron status.Hematology. American Society of Hematology. Education Program · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Belinda SpotoCNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Cal Unit, 89126, Italy. belinda.spoto@tin.it.
Rahul KakkarCorvidia, Waltham (MA), 02451, USA. rkakkar@corvidiatx.com.
Larry LoCorvidia, Waltham (MA), 02451, USA. llo@corvidiatx.com.
Matt DevalarajaCorvidia, Waltham (MA), 02451, USA. mdevalraja@corvidiatx.com.
Patrizia PizziniCNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Cal Unit, 89126, Italy. ppizzini@ifc.cnr.it.
Claudia TorinoCNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Cal Unit, 89126, Italy. ctorino@ifc.cnr.it.
Daniela LeonardisCNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Cal Unit, 89126, Italy. dleonardis@ifc.cnr.it.
Sebastiano CutrupiCNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Cal Unit, 89126, Italy. scutrupi@ifc.cnr.it.
Giovanni TripepiCNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Cal Unit, 89126, Italy. gtripepi@ifc.cnr.it.
Francesca MallamaciCNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Cal Unit, 89126, Italy. francesca.mallamaci@libero.it.
Carmine ZoccaliCNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Cal Unit, 89126, Italy. carmine.zoccali@tin.it.
Istituto di Fisiologia Clinica · ITNvidia (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erythroferrone (ERFE) is a hepcidin inhibitor whose synthesis is stimulated by erythropoietin, which increases iron absorption and mobilization. We studied the association between serum ERFE and mortality and non-fatal cardiovascular (CV) events in a cohort of 1123 hemodialysis patients and in a cohort of 745 stage 1-5 chronic kidney disease (CKD) patients. Erythroferrone was measured by a validated enzyme-linked immunosorbent assay (ELISA). In the hemodialysis cohort, serum ERFE associated directly with erythropoiesis stimulating agents (ESA) dose (

Indexed as

chronic kidney diseasedialysiserythroferroneironmortality

Identifiers

PMID30995819
PMCPMC6518296
OpenAlexW2937108409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.