Evidence map›Paper›PMID 30995772›Full record

ArticlePharmaceutics2019

Phospholipid-Based Prodrugs for Colon-Targeted Drug Delivery: Experimental Study and In-Silico Simulations.

Milica Markovic, Arik Dahan, Shahar Keinan, Igor Kurnikov, Aaron Aponick, Ellen M Zimmermann, Shimon Ben-Shabat

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells.Chembiochem : a European journal of chemical biology · 2026
    Review
  2. PLAPharmaceutics · 2022
    Article
  3. Article
  4. Review
  5. Computational Simulations to Guide Enzyme-Mediated Prodrug Activation.International journal of molecular sciences · 2020
    Review
  6. Lipids and Lipid-Processing Pathways in Drug Delivery and Therapeutics.International journal of molecular sciences · 2020
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Milica MarkovicDepartment of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. milica@post.bgu.ac.il.
Arik DahanDepartment of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. arikd@bgu.ac.il.ORCID 0000-0002-3498-3514
Shahar KeinanCloud Pharmaceuticals Inc., Durham, NC 27709, USA. skeinan@cloudpharmaceuticals.com.ORCID 0000-0001-8703-901X
Igor KurnikovCloud Pharmaceuticals Inc., Durham, NC 27709, USA. igor@cloudpharmaceuticals.com.
Aaron AponickDepartment of Chemistry, University of Florida, Gainesville, FL 32603, USA. aaron.aponick@gmail.com.ORCID 0000-0002-4576-638X
Ellen M ZimmermannDepartment of Medicine, Division of Gastroenterology, University of Florida, Gainesville, FL 32603, USA. Ellen.Zimmermann@medicine.ufl.edu.
Shimon Ben-ShabatDepartment of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. sbs@bgu.ac.il.ORCID 0000-0001-7551-5488
Ben-Gurion University of the Negev · ILCloud Pharmaceuticals (United States) · USUniversity of Florida · US

Funding

United States-Israel Binational Science Foundation 2015365
6 · The paper itself

Abstract

In ulcerative colitis (UC), the inflammation is localized in the colon, and one of the successful strategies for colon-targeting drug delivery is the prodrug approach. In this work, we present a novel phospholipid (PL)-based prodrug approach, as a tool for colonic drug targeting in UC. We aim to use the phospholipase A

Indexed as

colon-targeted drug deliverymolecular dynamicsPhospholipase A2prodrug approachulcerative colitis

Identifiers

PMID30995772
PMCPMC6523355
OpenAlexW2938341668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.