ArticlePolymers2019
Effect of Solution Composition Variables on Electrospun Alginate Nanofibers: Response Surface Analysis.
Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Towards Enhanced Electrospinning of Alginate-Can Recent Strategies Overcome Limitations? A Review.Polymers · 2025Review
- Alginate-Based Electrospun Nanofibers and the Enabled Drug Controlled Release Profiles: A Review.Biomolecules · 2024Review
- Development of Hybrid Electrospun Nanofibers: Improving Effects of Cellulose Nanofibers (CNFs) on Electrospinnability of Gelatin.Foods (Basel, Switzerland) · 2024Article
- The Potential of Electrospun Membranes in the Treatment of Textile Wastewater: A Review.Polymers · 2024Review
- Development of hybrid electrospun alginate-pulverized moringa composites.RSC advances · 2024Article
- Explicit Expressions for a Mean Nanofibre Diameter Using Input Parameters in the Process of Electrospinning.Polymers · 2023Article
- Alumina Ceramic Nanofibers: An Overview of the Spinning Gel Preparation, Manufacturing Process, and Application.Gels (Basel, Switzerland) · 2023Review
- Development of Nanofibers with Embedded Liposomes Containing an Immunomodulatory Drug Using Green Electrospinning.Pharmaceutics · 2023Article
- Nanofiber Carriers of Therapeutic Load: Current Trends.International journal of molecular sciences · 2022Review
- Influence of Excipient Composition on Survival of Vaginal Lactobacilli in Electrospun Nanofibers.Pharmaceutics · 2022Article
- Research progress, models and simulation of electrospinning technology: a review.Journal of materials science · 2022Review
- Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system by electrospinning method.Iranian journal of basic medical sciences · 2021Article
- Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning.Pharmaceutics · 2021Article
- Electrospun Poly(ethylene Terephthalate)/Silk Fibroin Composite for Filtration Application.Polymers · 2021Article
- Article
- Role of Electrospinning Parameters on Poly(Lactic-co-Glycolic Acid) and Poly(Caprolactone-co-Glycolic acid) Membranes.Polymers · 2021Article
- Biomaterials to Prevent Post-Operative Adhesion.Materials (Basel, Switzerland) · 2020Review
- Electrospun Alginate Nanofibers Toward Various Applications: A Review.Materials (Basel, Switzerland) · 2020Review
- High Efficiency Fabrication of Chitosan Composite Nanofibers with Uniform Morphology via Centrifugal Spinning.Polymers · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Alginate is a promising biocompatible and biodegradable polymer for production of nanofibers for drug delivery and tissue engineering. However, alginate is difficult to electrospin due to its polyelectrolyte nature. The aim was to improve the 'electrospinability' of alginate with addition of exceptionally high molecular weight poly(ethylene oxide) (PEO) as a co-polymer. The compositions of the polymer-blend solutions for electrospinning were varied for PEO molecular weight, total (alginate plus PEO) polymer concentration, and PEO proportion in the dry alginate-PEO polymer mix used. These were tested for rheology (viscosity, complex viscosity, storage and loss moduli) and conductivity, and the electrospun nanofibers were characterized by scanning electron microscopy. One-parameter-at-a-time approach and response surface methodology (RSM) were used to optimize the polymer-blend solution composition to obtain defined nanofibers. Both approaches revealed that the major influence on nanofiber formation and diameter were total polymer concentration and PEO proportion. These polymer-blend solutions of appropriate conductivity and viscosity enabled fine-tuning of nanofiber diameter. PEO molecular weight of 2-4 million Da greatly improved the electrospinnability of alginate, producing nanofibers with >85% alginate. This study shows that RSM can be used to design nanofibers with optimal alginate and co-polymer contents to provide efficient scaffold material for regenerative medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.