ArticlePolymers2019
Upper Critical Solution Temperature (UCST) Behavior of Coacervate of Cationic Protamine and Multivalent Anions.
Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
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- Bottom-up Strategies for Generating Polymer Protocells That Mimic Cellular Communication.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Selective Ion Binding and Uptake Shape the Microenvironment of Biomolecular Condensates.Journal of the American Chemical Society · 2025Article
- Rapid Solidification of Plant Latices fromPlants (Basel, Switzerland) · 2025Article
- Reversible and size-controlled assembly of reflectin proteins using a charged azobenzene photoswitch.Chemical science · 2024Article
- Solid-Liquid-Solution Phases in Poly(diallyldimethylammonium)/Poly(acrylic acid) Polyelectrolyte Complexes at Varying Temperatures.Macromolecules · 2024Article
- Liquid-liquid separation in gut immunity.Frontiers in immunology · 2024Review
- Using Implicit-Solvent Potentials to Extract Water Contributions to Enthalpy-Entropy Compensation in Biomolecular Associations.The journal of physical chemistry. B · 2023Article
- In Vitro Transcription-Translation in an Artificial Biomolecular Condensate.ACS synthetic biology · 2023Article
- Hydrophobicity of arginine leads to reentrant liquid-liquid phase separation behaviors of arginine-rich proteins.Nature communications · 2022Article
- Review
- Article
- Impact of Arginine-Phosphate Interactions on the Reentrant Condensation of Disordered Proteins.Biomacromolecules · 2021Article
- Temperature-Responsive Peptide-Nucleotide Coacervates.The journal of physical chemistry. B · 2021Article
- Constrained thermoresponsive polymers - new insights into fundamentals and applications.Beilstein journal of organic chemistry · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Complex coacervation is an emerging liquid/liquid phase separation (LLPS) phenomenon that behaves as a membrane-less organelle in living cells. Yet while one of the critical factors for complex coacervation is temperature, little analysis and research has been devoted to the temperature effect on complex coacervation. Here, we performed a complex coacervation of cationic protamine and multivalent anions (citrate and tripolyphosphate (TPP)). Both mixtures (i.e., protamine/citrate and protamine/TPP) underwent coacervation in an aqueous solution, while a mixture of protamine and sodium chloride did not. Interestingly, the complex coacervation of protamine and multivalent anions showed upper critical solution temperature (UCST) behavior, and the coacervation of protamine and multivalent anions was reversible with solution temperature changes. The large asymmetry in molecular weight between positively charged protamine (~4 kDa) and the multivalent anions (<0.4 kDa) and strong electrostatic interactions between positively charged guanidine residues in protamine and multivalent anions were likely to contribute to UCST behavior in this coacervation system.
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