Evidence map›Paper›PMID 30995728›Full record

ReviewMicromachines2019

Sensors that Learn: The Evolution from Taste Fingerprints to Patterns of Early Disease Detection.

Nicolaos Christodoulides, Michael P McRae, Glennon W Simmons, Sayli S Modak, John T McDevitt

Open access · goldAbstract readReview
In one paragraph

Review in Micromachines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 14 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicolaos ChristodoulidesDepartment of Biomaterials, College of Dentistry, Bioengineering Institute, New York University, New York, NY 10010, USA. nicolaoschristo19@gmail.com.
Michael P McRaeDepartment of Biomaterials, College of Dentistry, Bioengineering Institute, New York University, New York, NY 10010, USA. michael.mcrae@nyu.edu.ORCID 0000-0002-2126-9442
Glennon W SimmonsDepartment of Biomaterials, College of Dentistry, Bioengineering Institute, New York University, New York, NY 10010, USA. glennon.simmons@nyu.edu.
Sayli S ModakDepartment of Biomaterials, College of Dentistry, Bioengineering Institute, New York University, New York, NY 10010, USA. sayli.modak@nyu.edu.
John T McDevittDepartment of Biomaterials, College of Dentistry, Bioengineering Institute, New York University, New York, NY 10010, USA. mcdevitt@nyu.edu.
New York University · US

Funding

Effects of Oral Inflammation on the Levels of Salivary Biomarkers of AMIU01DE017793 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI MCDEVITT, JOHN T · 2006 to 2012
$13.0M
Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip EnsemblesRC2DE020785 · NIDCR · RICE UNIVERSITY · PI MCDEVITT, JOHN T · 2009 to 2012
$3.5M
NIDCR NIH HHS RC2 DE020785NIDCR NIH HHS U01 DE017793
6 · The paper itself

Abstract

The McDevitt group has sustained efforts to develop a programmable sensing platform that offers advanced, multiplexed/multiclass chem-/bio-detection capabilities. This scalable chip-based platform has been optimized to service real-world biological specimens and validated for analytical performance. Fashioned as a sensor that learns, the platform can host new content for the application at hand. Identification of biomarker-based fingerprints from complex mixtures has a direct linkage to e-nose and e-tongue research. Recently, we have moved to the point of big data acquisition alongside the linkage to machine learning and artificial intelligence. Here, exciting opportunities are afforded by multiparameter sensing that mimics the sense of taste, overcoming the limitations of salty, sweet, sour, bitter, and glutamate sensing and moving into fingerprints of health and wellness. This article summarizes developments related to the electronic taste chip system evolving into a platform that digitizes biology and affords clinical decision support tools. A dynamic body of literature and key review articles that have contributed to the shaping of these activities are also highlighted. This fully integrated sensor promises more rapid transition of biomarker panels into wide-spread clinical practice yielding valuable new insights into health diagnostics, benefiting early disease detection.

Indexed as

biomarkersbiosensorsearly disease detectionelectronic taste chipelectronic tonguepoint-of-careprogrammable bio-nano-chip (p-BNC)salivaserum

Identifiers

PMID30995728
PMCPMC6523560
OpenAlexW2939564225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.