Evidence map›Paper›PMID 30995723›Full record

ArticleJournal of clinical medicine2019

Bicuspid Aortic Valve Alters Aortic Protein Expression Profile in Neonatal Coarctation Patients.

Katie L Skeffington, Andrew R Bond, Safa Abdul-Ghani, Dominga Iacobazzi, Sok-Leng Kang, Kate J Heesom, Marieangela C Wilson, Mohamed Ghorbel, Serban Stoica, Robin Martin and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Katie L SkeffingtonBristol Heart Institute, Research Floor Level 7, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8HW, UK. katie.skeffington@bristol.ac.uk.ORCID 0000-0001-5252-6459
Andrew R BondBristol Heart Institute, Research Floor Level 7, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8HW, UK. Andrew.Bond@bristol.ac.uk.ORCID 0000-0002-4255-4488
Safa Abdul-GhaniBristol Heart Institute, Research Floor Level 7, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8HW, UK. salghani@staff.alquds.edu.
Dominga IacobazziBristol Heart Institute, Research Floor Level 7, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8HW, UK. mdxdi@bristol.ac.uk.
Sok-Leng KangDepartment of Congenital Heart Disease, King David Building, Upper Maudlin Street, Bristol BS2 8JB, UK. soklengkang@doctors.org.uk.
Kate J HeesomProteomics Facility, University of Bristol, Bristol BS8 1TD, UK. K.Heesom@bristol.ac.uk.
Marieangela C WilsonProteomics Facility, University of Bristol, Bristol BS8 1TD, UK. Maz.Wilson@bristol.ac.uk.
Mohamed GhorbelBristol Heart Institute, Research Floor Level 7, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8HW, UK. M.Ghorbel@bristol.ac.uk.
Serban StoicaDepartment of Congenital Heart Disease, King David Building, Upper Maudlin Street, Bristol BS2 8JB, UK. mdzscs@bristol.ac.uk.
Robin MartinDepartment of Congenital Heart Disease, King David Building, Upper Maudlin Street, Bristol BS2 8JB, UK. Rob.Martin@UHBristol.nhs.uk.
M Saadeh SuleimanBristol Heart Institute, Research Floor Level 7, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8HW, UK. M.S.Suleiman@bristol.ac.uk.
Massimo CaputoBristol Heart Institute, Research Floor Level 7, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8HW, UK. M.Caputo@bristol.ac.uk.
Bristol Royal Infirmary · GBUniversity of Bristol · GB

Funding

British Heart Foundation CH/17/1/32804British Heart Foundation PG/15/33/31394British Heart Foundation R120592-101
6 · The paper itself

Abstract

Coarctation of the aorta is a form of left ventricular outflow tract obstruction in paediatric patients that can be presented with either bicuspid (BAV) or normal tricuspid (TAV) aortic valve. The congenital BAV is associated with hemodynamic changes and can therefore trigger different molecular remodelling in the coarctation area. This study investigated the proteomic and phosphoproteomic changes associated with BAV for the first time in neonatal coarctation patients. Aortic tissue was collected just proximal to the coarctation site from 23 neonates (BAV;

Indexed as

aortic coarctationbicuspid aortic valvecongenital heart disease

Identifiers

PMID30995723
PMCPMC6518196
OpenAlexW2936730635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.