ArticlePhysics in medicine and biology2019
Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.
Article in Physics in medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Changes in bubble-cloud dissolution throughout the application of histotripsy pulses.Physical review applied · 2025Article
- Review
- Chirp-Coded Subharmonic Imaging With Volterra Filtering: Histotripsy Bubble Cloud Assessment In Vitro and Ex Vivo.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Dynamic mode decomposition based Doppler monitoring of de novo cavitation induced by pulsed HIFU: an in vivo feasibility study.Scientific reports · 2024Article
- Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound.Annual review of biomedical engineering · 2024Review
- Cavitation-induced pressure saturation: a mechanism governing bubble nucleation density in histotripsy.Physics in medicine and biology · 2024Article
- Quantifying the Effect of Acoustic Parameters on Temporal and Spatial Cavitation Activity: Gauging Cavitation Dose.Ultrasound in medicine & biology · 2023Article
- Contrast-Enhanced Imaging of Histotripsy Bubble Clouds Using Chirp-Coded Excitation and Volterra Filtering.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Assessment of bubble activity generated by histotripsy combined with echogenic liposomes.Physics in medicine and biology · 2022Article
- Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors.Diagnostics (Basel, Switzerland) · 2022Review
- Histotripsy Bubble Cloud Contrast With Chirp-Coded Excitation in Preclinical Models.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging.Physics in medicine and biology · 2021Article
- In vitro assessment of stiffness-dependent histotripsy bubble cloud activity in gel phantoms and blood clots.Physics in medicine and biology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Focused ultrasound therapies are a noninvasive means to ablate tissue. Histotripsy utilizes short ultrasound pulses with sufficient tension to nucleate bubble clouds that impart lethal strain to the surrounding tissues. Tracking bubble cloud dissolution between the application of histotripsy pulses is critical to ensure treatment efficacy. In this study, plane wave B-mode imaging was employed to monitor bubble cloud motion and grayscale at frame rates up to 11.25 kHz. Minimal changes in the area or position of the bubble clouds were observed 50 ms post excitation. The bubble cloud grayscale was observed to decrease with the square root of time, indicating a diffusion-driven process. These results were qualitatively consistent with an analytic model of gas diffusion during the histotripsy process. Finally, the rate of bubble cloud dissolution was found to be dependent on the output of the imaging pulse, indicating an interaction between the bubble cloud and imaging parameters. Overall, these results highlight the utility of plane wave B-mode imaging for monitoring histotripsy bubble clouds.
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