Evidence map›Paper›PMID 30995611›Full record

Trial reportPhysics in medicine and biology2019

Localization of liver lesions in abdominal CT imaging: I. Correlation of human observer performance between anatomical and uniform backgrounds.

Samantha K N Dilger, Lifeng Yu, Baiyu Chen, Chris P Favazza, Rickey E Carter, Joel G Fletcher, Cynthia H McCollough, Shuai Leng

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Physics in medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Automated Web-based Software for CT Quality Control Testing of Low-contrast Detectability using Model Observers.Proceedings of SPIE--the International Society for Optical Engineering · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A Web-Based Software Platform for Efficient and Quantitative CT Image Quality Assessment and Protocol Optimization.Proceedings of SPIE--the International Society for Optical Engineering · 2021
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Samantha K N DilgerDepartment of Radiology, Mayo Clinic, Rochester, MN, United States of America.ORCID 0000-0002-3524-1723
Lifeng YuDepartment of Radiology, Mayo Clinic, Rochester, MN, United States of America.
Baiyu ChenDepartment of Radiology, Mayo Clinic, Rochester, MN, United States of America.
Chris P FavazzaDepartment of Radiology, Mayo Clinic, Rochester, MN, United States of America.
Rickey E CarterDepartment of Biostatistics, Mayo Clinic, Rochester, MN, United States of America.
Joel G FletcherDepartment of Radiology, Mayo Clinic, Rochester, MN, United States of America.
Cynthia H McColloughDepartment of Radiology, Mayo Clinic, Rochester, MN, United States of America.
Shuai LengDepartment of Radiology, Mayo Clinic, Rochester, MN, United States of America.
Mayo Clinic in Florida · USMayo Clinic · USNYU Langone Health · US

Funding

Trade-offs in human observer performance, image quality metrics, and patient doseR01EB017095 · NIBIB · MAYO CLINIC ROCHESTER · PI Hao Gong, Cynthia H McCollough · 2012 to 2026
$7.0M
Critical resources to evaluate CT scan techniques and dose reduction approachesU01EB017185 · NIBIB · MAYO CLINIC ROCHESTER · PI MCCOLLOUGH, CYNTHIA H · 2013 to 2016
$3.6M
NIBIB NIH HHS R01 EB017095NIBIB NIH HHS U01 EB017185
6 · The paper itself

Abstract

The purpose of this study was to determine the correlation between human observer performance for localization of small low contrast lesions within uniform water background versus an anatomical liver background, under the conditions of varying dose, lesion size, and reconstruction algorithm. Liver lesions (5 mm, 7 mm, and 9 mm, contrast:  -21 HU) were digitally inserted into CT projection data of ten normal patients in vessel-free liver regions. Noise was inserted into the projection data to create three image sets: full dose and simulated half and quarter doses. Images were reconstructed with a standard filtered back projection (FBP) and an iterative reconstruction (IR) algorithm. Lesion and noise insertion procedures were repeated with water phantom data. Two-dimensional regions of interest (66 lesion-present, 34 lesion-absent) were selected, randomized, and independently reviewed by three medical physicists to identify the most likely location of the lesion and provide a confidence score. Locations and confidence scores were assessed using the area under the localization receiver operating characteristic curve (Az

Indexed as

Observer VariationPhantoms, ImagingAlgorithmsHumansLiver NeoplasmsRadiation DosageRadiographic Image Interpretation, Computer-AssistedRadiography, AbdominalROC CurveTomography, X-Ray Computed

Identifiers

PMID30995611
PMCPMC6598706
OpenAlexW2938269440

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.