ArticlePloS one2019
Repeatability of brown adipose tissue measurements on FDG PET/CT following a simple cooling procedure for BAT activation.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Circulating succinate changes during acute cold exposure are not related with brown adipose tissue in humans.Journal of physiology and biochemistry · 2026Trial
- Uncoupling Protein 1 Does Not Produce Heat without Activation.International journal of molecular sciences · 2022Review
- Activating Human Adipose Tissue with the β3-Adrenergic Agonist Mirabegron.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The acclimatization of Haenyeo to a cold environment and occupational characteristics evaluated by orexin and irisin levels.Annals of occupational and environmental medicine · 2022Article
- Nutritional Regulation of Human Brown Adipose Tissue.Nutrients · 2021Review
- Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans.European journal of applied physiology · 2020Article
- Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection.Frontiers in endocrinology · 2020Review
- Reduced Beige Adipogenic Potential in Subcutaneous Adipocytes Derived from Obese Chinese Individuals.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brown Adipose Tissue (BAT) is present in a significant number of adult humans and can be activated by exposure to cold. Measurement of active BAT presence, activity, and volume are desirable for determining the efficacy of potential treatments intended to activate BAT. The repeatability of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) measurements of BAT presence, activity, and volume under controlled conditions has not been extensively studied. Eleven female volunteers underwent double baseline FDG PET imaging performed following a simple, regional cold intervention intended to activate brown fat. The cold intervention involved the lightly-clothed participants intermittently placing their feet on a block of ice while sitting in a cooled room. A repeat study was performed under the same conditions within a target of two weeks. FDG scans were obtained and maximum standardized uptake value adjusted for lean body mass (SULmax), CT Hounsfield units (HU), BAT metabolic volume (BMV), and total BAT glycolysis (TBG) were determined according to the Brown Adipose Reporting Criteria in Imaging STudies (BARCIST) 1.0. A Lin's concordance correlation (CCC) of 0.80 was found for BMV between test and retest imaging. Intersession BAT SULmax was significantly correlated (r = 0.54; p < 0.05). The session #1 mean SULmax of 4.92 ± 4.49 g/mL was not significantly different from that of session #2 with a mean SULmax of 7.19 ± 7.34 g/mL (p = 0.16). BAT SULmax was highly correlated with BMV in test and retest studies (r ≥ 0.96, p < 0.001). Using a simplified ice-block cooling method, BAT was activated in the majority (9/11) of a group of young, lean female participants. Quantitative assessments of BAT SUL and BMV were not substantially different between test and retest imaging, but individual BMV could vary considerably. Intrasession BMV and SULmax were strongly correlated. The variability in estimates of BAT activity and volume on test-retest with FDG should inform sample size choice in studies quantifying BAT physiology and support the dynamic metabolic characteristics of this tissue. A more sophisticated cooling method potentially may reduce variations in test-retest BAT studies.
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