ArticleAging2019
Cognitive fatigue and cortical-striatal network in old age.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Time/Movement Estimation and Mental Rotation Tasks as Early Cognitive Markers in Alzheimer's Disease.Brain and behavior · 2025Article
- Differential Fatigue Profile in Patients with Post-COVID Condition, Fibromyalgia, and Multiple Sclerosis.Journal of clinical medicine · 2025Article
- Vision-based estimation of fatigue and engagement in cognitive training sessions.Artificial intelligence in medicine · 2024Article
- Decoding visual fatigue in a visual search task selectively manipulated via myopia-correcting lenses.Frontiers in neuroscience · 2024Article
- Enhanced putamen functional connectivity underlies altered risky decision-making in age-related cognitive decline.Scientific reports · 2023Article
- A Multi-Dimensional Model of Fatigue in Old Age: Implications for Brain Aging.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Article
- Transcranial direct current stimulation for post-COVID fatigue: a randomized, double-blind, controlled pilot study.Brain communications · 2023Article
- Neuropsychological Predictors of Fatigue in Post-COVID Syndrome.Journal of clinical medicine · 2022Article
- Mild Parkinsonian Signs, Energy Decline, and Striatal Volume in Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Usability and Effectiveness of Immersive Virtual Grocery Shopping for Assessing Cognitive Fatigue in Healthy Controls: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2021Article
- Brain structural connectomes indicate shared neural circuitry involved in subjective experience of cognitive and physical fatigue in older adults.Brain imaging and behavior · 2020Article
- Article
- Individual Differences in Interoceptive Accuracy Are Correlated With Salience Network Connectivity in Older Adults.Frontiers in aging neuroscience · 2020Article
- Commentary: A posterior-to-anterior shift of brain functional dynamics in aging.Frontiers in aging neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cognitive fatigue (CF) is among the most common and disturbing aging symptoms, and substantially interferes with activities demanding sustained mental effort. Here we examined the relationship between the cortical-striatal network and CF (assessed by the 18-item visual analogue scale) when a group of cognitively and physically healthy older adults participated in a 30-minute cognitively fatiguing task-related fMRI experiment. We also explored whether CF would interfere with the "Posterior-Anterior Shifting in Aging" (PASA) phenomenon, an aging-associated neural reliance on frontal regions to support cognitive capacity. We revealed that decreased connectivity strength of the cortical-striatal network over the course of the task was related to higher CF. Correlation between CF and the cortical-striatal network was more robust in anterior relative to posterior components. Moreover, a positive relationship between reliance on the anterior part of the cortical-striatal network and cognitive performance only existed among older adults experiencing low CF. These findings suggest a crucial role of the cortical-striatal network, especially the anterior component, in linking to CF. The PASA phenomenon may only be applicable to older adults without vulnerability to CF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.