Evidence map›Paper›PMID 30995155›Full record

ArticleMolecular biology of the cell2019

Role of KASH domain lengths in the regulation of LINC complexes.

Zeinab Jahed, Hongyan Hao, Vyom Thakkar, Uyen T Vu, Venecia A Valdez, Akshay Rathish, Chris Tolentino, Samuel C J Kim, Darya Fadavi, Daniel A Starr and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Nuclear movement in multinucleated cells.Development (Cambridge, England) · 2022
    Review
  9. Review
  10. Article
  11. LINCing Nuclear Mechanobiology With Skeletal Muscle Mass and Function.Frontiers in cell and developmental biology · 2021
    Review
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Zeinab JahedMolecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720.
Hongyan HaoDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616.
Vyom ThakkarMolecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720.
Uyen T VuMolecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720.
Venecia A ValdezDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616.
Akshay RathishMolecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720.
Chris TolentinoMolecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720.
Samuel C J KimMolecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720.
Darya FadaviMolecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720.
Daniel A StarrDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616.
Mohammad R K MofradMolecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720.
University of California, Berkeley · USUniversity of California, Davis · USLawrence Berkeley National Laboratory · US

Funding

Mechanisms of Nuclear Migration and AnchorageR01GM073874 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI STARR, DANIEL A · 2006 to 2019
$4.5M
NIGMS NIH HHS R01 GM073874
6 · The paper itself

Abstract

The linker of the nucleoskeleton and cytoskeleton (LINC) complex is formed by the conserved interactions between Sad-1 and UNC-84 (SUN) and Klarsicht, ANC-1, SYNE homology (KASH) domain proteins, providing a physical coupling between the nucleoskeleton and cytoskeleton that mediates the transfer of physical forces across the nuclear envelope. The LINC complex can perform distinct cellular functions by pairing various KASH domain proteins with the same SUN domain protein. For example, in

Indexed as

Amino Acid MotifsAmino Acid SequenceAnimalsBiomechanical PhenomenaCaenorhabditis elegansCell MembraneConserved SequenceHumansMultiprotein ComplexesNuclear EnvelopeProtein DomainsStructure-Activity RelationshipMultiprotein Complexes

Identifiers

PMID30995155
PMCPMC6727767
OpenAlexW2935850622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.