Evidence map›Paper›PMID 30995113›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Quantitative proteomic analysis of a genetically induced prostate inflammation mouse model via custom 4-plex DiLeu isobaric labeling.

Ling Hao, Samuel Thomas, Tyler Greer, Chad M Vezina, Sagar Bajpai, Arya Ashok, Angelo M De Marzo, Charles J Bieberich, Lingjun Li, William A Ricke

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ling HaoSchool of Pharmacy, University of Wisconsin-Madison , Madison, Wisconsin.
Samuel ThomasMolecular and Environmental Toxicology Center, University of Wisconsin-Madison , Madison, Wisconsin.
Tyler GreerDepartment of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin.
Chad M VezinaMolecular and Environmental Toxicology Center, University of Wisconsin-Madison , Madison, Wisconsin.
Sagar BajpaiDepartment of Biological Sciences, University of Maryland-Baltimore County , Baltimore, Maryland.
Arya AshokDepartment of Biological Sciences, University of Maryland-Baltimore County , Baltimore, Maryland.
Angelo M De MarzoDepartment of Pathology, Johns Hopkins University School of Medicine , Baltimore, Maryland.
Charles J BieberichDepartment of Biological Sciences, University of Maryland-Baltimore County , Baltimore, Maryland.
Lingjun LiSchool of Pharmacy, University of Wisconsin-Madison , Madison, Wisconsin.
William A RickeSchool of Pharmacy, University of Wisconsin-Madison , Madison, Wisconsin.ORCID 0000-0002-9807-2090
University of Wisconsin–Madison · USUniversity of Maryland, Baltimore County · USJohns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2016 to 2025
$13.1M
Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MACOSKA, JILL A., MARKER, PAUL C · 2014 to 2023
$12.8M
Molecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5M
Mass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7M
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF DIOXINR01ES001332 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI PETERSON, RICHARD EUGENE, VEZINA, CHAD M. · 1985 to 2021
$5.3M
Acquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical ResearchS10RR029531 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$2.1M
Ring-Opened and Tandem DNA DamagesR01ES013324 · NIEHS · UNIVERSITY OF CONNECTICUT STORRS · PI BASU, ASHIS K · 2006 to 2010
$1.5M
Role of Inflammation and Epigenetics in Benign Prostate PathologyP20DK090921 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI BIEBERICH, CHARLES J. · 2010 to 2012
$876k
Urinary Biomarkers of Lower Urinary Traxct Symptoms (LUTS) in Men P20DK097826 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI BUSHMAN, WADE A · 2012 to 2014
$776k
NCRR NIH HHS S10 RR029531NIDDK NIH HHS P20 DK090921NIDDK NIH HHS P20 DK097826NIDDK NIH HHS R01 DK071801NIDDK NIH HHS U54 DK104310NIEHS NIH HHS R01 ES001332NIEHS NIH HHS R01 ES013324NIEHS NIH HHS T32 ES007015NIGMS NIH HHS P41 GM108538
6 · The paper itself

Abstract

Inflammation is involved in many prostate pathologies including infection, benign prostatic hyperplasia, and prostate cancer. Preclinical models are critical to our understanding of disease mechanisms, yet few models are genetically tractable. Here, we present a comparative quantitative proteomic analysis of urine from mice with and without prostate-specific inflammation induced by conditional prostate epithelial IL-1β expression. Relative quantification and sample multiplexing was achieved using custom 4-plex

Indexed as

Isotope LabelingProteomeAnimalsBiomarkersChromatography, High Pressure LiquidDisease Models, AnimalHigh-Throughput Screening AssaysInflammation MediatorsLeucineMaleMice, TransgenicProstateProstatitisProteomicsTandem Mass SpectrometryTime FactorsBiomarkersInflammation MediatorsLeucineProteomebenign prostatic hyperplasiainflammationinterleukin-1βlower urinary tract symptoms, mass spectrometryurine proteomics

Identifiers

PMID30995113
PMCPMC6620594
OpenAlexW2936139387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.