ArticleThe American journal of sports medicine2019
Anterior Cruciate Ligament Tear Promotes Skeletal Muscle Myostatin Expression, Fibrogenic Cell Expansion, and a Decline in Muscle Quality.
Article in The American journal of sports medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 51 citations in OpenAlex.
- The Efficacy of Blood Flow Restriction Training to Improve Quadriceps Muscle Function after Anterior Cruciate Ligament Reconstruction.Medicine and science in sports and exercise · 2025Trial
- The Use of Recombinant Human Growth Hormone to Protect Against Muscle Weakness in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Pilot, Randomized Placebo-Controlled Trial.The American journal of sports medicine · 2020Trial
- The Effects of Anterior Cruciate Ligament Reconstruction on Individual Quadriceps Muscle Thickness and Circulating Biomarkers.International journal of environmental research and public health · 2019Trial
- Cellular senescence links muscle atrophy and posttraumatic osteoarthritis after ACL injury.Function (Oxford, England) · 2026Article
- ACL injury reprograms quadriceps myonuclear epigenetic and transcriptional signatures in mice.Molecular medicine (Cambridge, Mass.) · 2026Article
- Persistent bone and muscle deficits after anterior cruciate ligament reconstruction : implications for post-traumatic osteoarthritis risk.Bone & joint research · 2026Article
- Decreased Thigh Muscle Cross-Sectional Area Following Anterior Cruciate Ligament Injury Depends on Concomitant Meniscal Injury and Subject Sex.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Macrophages, muscle stem cells, and repair; immunohistochemical characteristics in muscle growth impairments in children with cerebral palsy.American journal of physiology. Cell physiology · 2026Article
- Muscle atrophy after ACL reconstruction involves molecular mechanisms beyond unloading.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury.BMC medicine · 2026Article
- Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy.Developmental medicine and child neurology · 2026Review
- Zinc deficiency contributes to blunted myogenesis in chronic kidney disease.American journal of physiology. Cell physiology · 2026Article
- Fork in the road: therapeutic and pathological actions for fibro-adipogenic progenitors following musculoskeletal injury.The Journal of physiology · 2025Review
- CSF1-R inhibition attenuates posttraumatic osteoarthritis and quadriceps atrophy following ligament injury.The Journal of physiology · 2025Article
- Overuse-Induced Muscle Disorder: Establishing a Rat Model to Unravel the Role of Fibro-Adipogenic Progenitor Cells in Intramuscular Fibrosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Relationships between diffusion tensor parameters and measures of skeletal muscle fiber size and strength after anterior cruciate ligament injury.Magnetic resonance imaging · 2025Article
- Quadriceps Morphology 6- to 60-Months After Anterior Cruciate Ligament Tear.Scandinavian journal of medicine & science in sports · 2025Article
- Nutritional Interventions to Attenuate Quadriceps Muscle Deficits following Anterior Cruciate Ligament Injury and Reconstruction.Sports medicine (Auckland, N.Z.) · 2025Review
- Muscle-specific ERRγ activation mitigates muscle atrophy after ACL injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Alterations in whole muscle quality and physiological cross-sectional area measured with quantitative MRI following ACL injury.Journal of translational medicine · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAnterior cruciate ligament (ACL) tears result in significant quadriceps muscle atrophy that is resistant to recovery despite extensive rehabilitation. Recent work suggests an elevated fibrotic burden in the quadriceps muscle after the injury, which may limit recovery. Elucidating the mechanisms and cell types involved in the progression of fibrosis is critical for developing new treatment strategies. PURPOSE: To identify factors contributing to the elevated fibrotic burden found after the injury. STUDY
designDescriptive laboratory study.
methodsAfter an ACL injury, muscle biopsy specimens were obtained from the injured and noninjured vastus lateralis of young adults (n = 14, mean ± SD: 23 ± 4 years). The expression of myostatin, transforming growth factor β, and other regulatory factors was measured, and immunohistochemical analyses were performed to assess turnover of extracellular matrix components.
resultsInjured limb skeletal muscle demonstrated elevated myostatin gene ( P < .005) and protein ( P < .0005) expression, which correlated ( R
conclusionThese findings support a role for myostatin in promoting fibrogenic alterations within skeletal muscle after an ACL injury. CLINICAL RELEVANCE: The current work shows that the cause of muscle quality decline after ACL injury likely involves elevated myostatin expression, and future studies should explore therapeutic inhibition of myostatin to facilitate improvements in muscle recovery and return to sport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.