ArticleThe International journal of eating disorders2019
Genetic risk, body mass index, and weight control behaviors: Unlocking the triad.
Article in The International journal of eating disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- From scroll to sale: online media engagement predicts adolescents' online supplement purchases in a nationally representative cross-sectional study.Frontiers in psychology · 2026Article
- The association between parental BMI and offspring adiposity: A genetically informed analysis of trios.PLoS genetics · 2025Article
- Relationships of eating behaviors with psychopathology, brain maturation and genetic risk for obesity in an adolescent cohort study.Nature. Mental health · 2025Article
- Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores.European eating disorders review : the journal of the Eating Disorders Association · 2022Article
- Polygenic association with severity and long-term outcome in eating disorder cases.Translational psychiatry · 2022Article
- Genetics of eating disorders in the genome-wide era.Psychological medicine · 2021Review
- Weight Goals, Disordered Eating Behaviors, and BMI Trajectories in US Young Adults.Journal of general internal medicine · 2021Article
- Association of Genetic and Phenotypic Assessments With Onset of Disordered Eating Behaviors and Comorbid Mental Health Problems Among Adolescents.JAMA network open · 2020Article
- Polygenic Score for Body Mass Index Is Associated with Disordered Eating in a General Population Cohort.Journal of clinical medicine · 2020Article
- Association of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts.PloS one · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe relationship between genetic risk for body mass index (BMI) and weight control behaviors remains unknown. The objectives of this study were to determine the association between genetic risk for BMI and weight control behaviors in young adults, and to examine actual measured BMI as a potential mediator variable.
methodWe analyzed data from three data collection waves of the National Longitudinal Study of Adolescent to Adult Health. The BMI polygenic score (PGS) was based on published genome-wide association studies for BMI. BMI was collected at 11-18 years and 18-26 years. Weight control behaviors included self-reported: (a) weight loss behaviors (dieting, vomiting, fasting/skipping meals, diet pills, laxatives, or diuretic use to lose weight) and (b) weight gain behaviors (eating more or different foods than normal, taking supplements to gain weight).
resultsAmong 4,397 participants, the BMI PGS was associated with higher odds of weight loss behaviors in females (OR 1.24, 95% CI 1.14-1.35) and males (OR 1.43, 95% CI 1.26-1.62), and this association was mediated by BMI (indirect effect 0.04, 95% CI 0.03-0.05 in females and 0.03, 95% CI 0.03-0.04 in males). The BMI PGS was associated with lower odds of weight gain behaviors in females and males, which was also mediated by actual BMI.
conclusionsThe BMI PGS was associated with weight loss behaviors in both males and females, and this association was mediated by actual measured BMI. Clinical interventions to prevent high BMI, particularly for individuals with genetic risk, may also prevent subsequent development of potentially unhealthy weight loss behaviors.
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