ArticleJournal of biological rhythms2019
Neuronal Activity in Non-LNv Clock Cells Is Required to Produce Free-Running Rest:Activity Rhythms in Drosophila.
Article in Journal of biological rhythms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Circadian control of a sex-specific behavior ineLife · 2026Article
- Circadian rhythms are more resilient to pacemaker neuron disruption in female Drosophila.PLoS biology · 2025Article
- The cell-intrinsic circadian clock is dispensable for lateral posterior clock neuron regulation ofNeurobiology of sleep and circadian rhythms · 2025Article
- Reorganization of circadian activity and the pacemaker circuit under novel light regimes.Proceedings. Biological sciences · 2024Article
- A four-oscillator model of seasonally adapted morning and evening activities in Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- A subclass of evening cells promotes the switch from arousal to sleep at dusk.Current biology : CB · 2024Article
- Dissecting neuron-specific functions of circadian genes using modified cell-specific CRISPR approaches.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dopamine and GPCR-mediated modulation of DN1 clock neurons gates the circadian timing of sleep.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hsp40 overexpression in pacemaker neurons delays circadian dysfunction in a Drosophila model of Huntington's disease.Disease models & mechanisms · 2022Article
- Central and Peripheral Clock Control of Circadian Feeding Rhythms.Journal of biological rhythms · 2021Article
- Dorsal clock neurons iniScience · 2021Article
- Article
- Integration of Circadian Clock Information in theJournal of biological rhythms · 2021Review
- Uncovering the Roles of Clocks and Neural Transmission in the Resilience ofFrontiers in physiology · 2021Article
- Entrainment of theNeuroscience insights · 2020Review
- Dissection of central clock function ineLife · 2019Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Circadian rhythms in behavior and physiology are produced by central brain clock neurons that can be divided into subpopulations based on molecular and functional characteristics. It has become clear that coherent behavioral rhythms result from the coordinated action of these clock neuron populations, but many questions remain regarding the organizational logic of the clock network. Here we used targeted genetic tools in Drosophila to eliminate either molecular clock function or neuronal activity in discrete clock neuron subsets. We find that neuronal firing is necessary across multiple clock cell populations to produce free-running rhythms of rest and activity. In contrast, such rhythms are much more subtly affected by molecular clock suppression in the same cells. These findings demonstrate that network connectivity can compensate for a lack of molecular oscillations within subsets of clock cells. We further show that small ventrolateral (sLNv) clock neurons, which have been characterized as master pacemakers under free-running conditions, cannot drive rhythms independent of communication between other cells of the clock network. In particular, we pinpoint an essential contribution of the dorsolateral (LNd) clock neurons, and show that manipulations that affect LNd function reduce circadian rhythm strength without affecting molecular cycling in sLNv cells. These results suggest a hierarchical organization in which circadian information is first consolidated among one or more clock cell populations before accessing output pathways that control locomotor activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.