Evidence map›Paper›PMID 30993986›Full record

ArticleOrganic letters2019

Site Selective Amide Reduction of Cyclosporine A Enables Diverse Derivation of an Important Cyclic Peptide.

Michael T Peruzzi, Fabrice Gallou, Stephen J Lee, Michel R Gagné

Abstract read
In one paragraph

Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Site-Selective Copper(I)-Catalyzed Hydrogenation of Amides.Journal of the American Chemical Society · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael T PeruzziCaudill Laboratories, Department of Chemistry , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-3290 , United States.
Fabrice GallouChemical and Analytical Development - Novartis Pharma AG , Basel , Switzerland.
Stephen J LeeU.S. Army Research Office , P.O. Box 12211, Research Triangle Park , North Carolina 27709 , United States.
Michel R GagnéCaudill Laboratories, Department of Chemistry , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-3290 , United States.ORCID 0000-0001-8424-5547

Funding

Methods for Chemo- and Site-Selective C-O activation in Bioactive Natural ProductsR01GM130693 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GAGNE, MICHEL R · 2018 to 2021
$1.3M
NIGMS NIH HHS R01 GM130693
6 · The paper itself

Abstract

Site selective amide reductions of the cyclic undecapeptide, cyclosporine A, have been developed using the combination of a heteroleptic borane catalyst and a silane reductant. Tertiary silane Me

Indexed as

AmidesAminesBoranesCatalysisCyclosporineOxidation-ReductionPeptides, CyclicSilanesAmidesAminesBoranesCyclosporinePeptides, CyclicSilanes

Identifiers

PMID30993986
PMCPMC7328826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.