Evidence map›Paper›PMID 30993934›Full record

ArticleKorean journal of radiology2019

Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging.

Yongfang Wang, Xin Zhang, Bin Wang, Yang Xie, Yi Wang, Xuan Jiang, Rongjia Wang, Ke Ren

Abstract read
In one paragraph

Article in Korean journal of radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Assessment of Acute Kidney Injury using MRI.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  7. Impact ofFrontiers in pharmacology · 2025
    Article
  8. Review
  9. Article
  10. Research progress on animal models of contrast-induced acute kidney injury.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yongfang WangDepartment of Radiology, First Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-4804-3566
Xin ZhangDepartment of Radiology, First Hospital of China Medical University, Shenyang, China.ORCID 0000-0003-1862-3495
Bin WangDepartment of Radiology, First Hospital of Shanxi Medical University, Taiyuan, China.ORCID 0000-0002-7767-4930
Yang XieDepartment of Radiology, First Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-2892-0613
Yi WangDepartment of Radiology, The Qianfoshan Hospital of Shandong Province, Jinan, China.ORCID 0000-0002-1832-0876
Xuan JiangCardiac Surgery, First Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-3950-9504
Rongjia WangDepartment of Radiology, First Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-9457-4093
Ke RenDepartment of Radiology, First Hospital of China Medical University, Shenyang, China. renke815@sina.com.ORCID 0000-0002-5735-055X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the potential of intravoxel incoherent motion (IVIM) and blood oxygen level-dependent (BOLD) magnetic resonance imaging for detecting renal changes after iodinated contrast-induced acute kidney injury (CI-AKI) development in a diabetic rabbit model. MATERIALS AND

methodsSixty-two rabbits were randomized into 2 groups: diabetic rabbits with the contrast agent (DCA) and healthy rabbits with the contrast agent (NCA). In each group, 6 rabbits underwent IVIM and BOLD imaging at 1 hour, 1 day, 2 days, 3 days, and 4 days after an iohexol injection while 5 rabbits were selected to undergo blood and histological examinations at these specific time points. Iohexol was administrated at a dose of 2.5 g I/kg of body weight. Further, the apparent transverse relaxation rate (R2*), average pure molecular diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) were calculated.

resultsThe D and f values of the renal cortex (CO) and outer medulla (OM) were significantly decreased compared to baseline values in the 2 groups 1 day after the iohexol injection (

conclusionA combination of IVIM and BOLD imaging may serve as a noninvasive method for detecting and monitoring CI-AKI in the early stages in the diabetic kidney.

Indexed as

Magnetic Resonance ImagingAcute Kidney InjuryAnimalsContrast MediaDiabetes MellitusDisease Models, AnimalHemodynamicsIodineKidneyMaleOxygenRabbitsContrast MediaIodineOxygenHypoxia-inducible transcription factor-1αMedullary hypoxiaRenal vascular dysfunctionVascular endothelial growth factor

Identifiers

PMID30993934
PMCPMC6470079

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.