Evidence map›Paper›PMID 30993908›Full record

ArticleBrain and behavior2019

Emotion sensitivity and self-reported symptoms of generalized anxiety disorder across the lifespan: A population-based sample approach.

Lauren A Rutter, Luke Scheuer, Ipsit V Vahia, Brent P Forester, Jordan W Smoller, Laura Germine

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

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  6. Morphological similarity of amygdala-ventral prefrontal pathways represents trait anxiety in younger and older adults.Proceedings of the National Academy of Sciences of the United States of America · 2022
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  15. Progressive brain structural alterations assessed via causal analysis in patients with generalized anxiety disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lauren A RutterInstitute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts.ORCID 0000-0002-8852-7602
Luke ScheuerInstitute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts.
Ipsit V VahiaInstitute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts.
Brent P ForesterDepartment of Psychiatry, Harvard Medical School, Belmont, Massachusetts.
Jordan W SmollerDepartment of Psychiatry, Harvard Medical School, Belmont, Massachusetts.
Laura GermineInstitute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts.
Harvard University · USBroad Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndividuals with generalized anxiety disorder (GAD) symptoms show deficits in emotion processing, but results of prior studies have been conflicting, and little is known about developmental trajectories of emotion processing over time. We examined the association between GAD symptoms and sensitivity to recognizing emotional facial expressions (emotion sensitivity: ES) for three emotions (happiness, anger, fear) in a large, diverse, population-based sample. We hypothesized that higher anxiety scores would be associated with poorer performance, and expected that ES performance and anxiety scores would decline across the lifespan.

methodParticipants were 7,176 responders to a web-based ES study (age range = 10-96 years old).

resultsHigher GAD-7 scores were associated with poorer ES performance for all emotion categories (happiness, anger, fear). The relationship between GAD-7 and ES scores remained significant after controlling for the effects of age and sex, and there was no significant interaction, indicating that the relationship does not change across age. Age significantly predicted ES and GAD-7 scores across emotions, with older ages showing lower ES scores and lower anxiety.

conclusionsIn the largest study of its kind, GAD symptoms were associated with impaired ES performance across three emotion types. Future research should explore the connection between anxiety symptoms, cognitive processing, and social processing to better characterize the mechanisms of how GAD is linked with both social and non-social information processing. Future work may also look at if ES is related over time to changes in anxiety, making it a promising target for intervention.

Indexed as

Facial ExpressionSelf ReportAdolescentAdultAgedAged, 80 and overAge FactorsAngerAnxietyAnxiety DisordersChildEmotionsFearFemaleHappinessHumansemotion perceptiongeneralized anxiety disorderlifespan

Identifiers

PMID30993908
PMCPMC6576169
OpenAlexW2940171619

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.