ArticleNeurogastroenterology and motility2019
Chronic daily opioid exposure is associated with dysphagia, esophageal outflow obstruction, and disordered peristalsis.
Article in Neurogastroenterology and motility, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 80 citations in OpenAlex.
- Opioids to Treat Chronic Pain in the Older Adult: A Clinical Consensus to Guarantee Safety and Avoid Adverse Events.Drugs & aging · 2026Review
- Unravelling the Links Between Gastroesophageal Reflux and Lung Disease: New Insights.Digestive diseases and sciences · 2026Review
- Dysphagia is associated with major esophageal motility disorders in the UAE: a retrospective cohort study from a tertiary care center in Abu Dhabi.BMC gastroenterology · 2026Article
- Perioperative Outcomes in Simple Cystectomy for Neurogenic Lower Urinary Tract Dysfunction: A Comparison of Surgical Approach, Surgical Teams, and Alvimopan Use.International neurourology journal · 2025Article
- Gastrointestinal complications in intensive care.Medical review (2021) · 2025Review
- Changes in esophageal contractile and barrier function in lung transplant recipients.Esophagus : official journal of the Japan Esophageal Society · 2025Article
- The Effects of Chronic Opioid Therapy on Achalasia and the Upper Esophageal Sphincter.Medical sciences (Basel, Switzerland) · 2025Article
- The Esophageal Response to Distension on Functional Lumen Imaging Probe Panometry Is Minimally Changed by Conscious Sedation in Healthy Asymptomatic Subjects.Journal of neurogastroenterology and motility · 2025Article
- Esophagogastric Junction Outflow Obstruction (EGJOO): A Manometric Phenomenon or Clinically Impactful Problem.Current gastroenterology reports · 2024Review
- Article
- Serotonin therapies for opioid-induced disordered swallow and respiratory depression.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Effects of Codeine on Esophageal Peristalsis in Patients With Ineffective Esophageal Motility: Studies Using High-resolution Manometry.Journal of neurogastroenterology and motility · 2024Article
- The integrated relaxation pressure may not be an appropriate gold standard for deglutitive relaxation due to reliance on a single intragastric reference sensor.Neurogastroenterology and motility · 2023Article
- Comparing Patients Diagnosed With Ineffective Esophageal Motility by the Chicago Classification Version 3.0 and Version 4.0 Criteria.Gastroenterology research · 2023Article
- Impact of opioids on treatment response among idiopathic esophagogastric junction outflow obstruction patients: A retrospective cohort study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- Non-Acid Fluid Exposure and Esophageal Squamous Cell Carcinoma.Digestive diseases and sciences · 2022Review
- Esophageal Motility Disorders: Current Approach to Diagnostics and Therapeutics.Gastroenterology · 2022Review
- Prospective evaluation of complications associated with transesophageal echocardiography in dogs with congenital heart disease.Journal of veterinary internal medicine · 2022Article
- Chronic opioid use is associated with obstructive and spastic disorders in the esophagus.Neurogastroenterology and motility · 2022Article
- [Chicago Classification ver. 4.0: An Overview of Esophageal Motility Disorders on High-resolution Manometry].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOpioid receptors are present in the esophagus, and chronic opioid therapy may be associated with esophageal dysfunction. Given the current opioid epidemic in the United States, the potential contribution of opioids to esophageal dysmotility is important from both public health and patient care perspectives. Therefore our aim is to investigate the potential contribution of opioids to dysphagia and the prevalence of major motor disorders in patients undergoing manometric evaluation.
methodsThe anonymized electronic medical records of patients linked to their de-identified high-resolution manometry (HRM) studies were reviewed. The patients were grouped based on their opioid exposure history at the time of HRM: opioid-naïve and chronic daily users. The oral morphine milligram equivalent daily dose (MMED) of opioids was computed. KEY
results10% of patients referred for esophageal HRM were taking opioid analgesics on a chronic daily basis, and they had a significantly higher prevalence of dysphagia than their opioid-naïve counterparts. The chronic daily opioid users displayed a significantly higher prevalence of achalasia type 3 (ACH3) and esophagogastric junction outflow obstruction (EGJOO) motility phenotypes. The MMED of opioids was a significant predictor of esophageal pressure metrics and motility diagnoses (P < 0.0001).
conclusionsChronic daily opioid intake is associated with impaired deglutitive LES relaxation and disorganized peristaltic sequence. While a minority of patients on chronic daily opioid therapy present with major esophageal motor disorders, they comprise nearly half of ACH3 and a third of EGJOO motility phenotypes.
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Registered trials
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