Evidence map›Paper›PMID 30993709›Full record

ArticleJournal of anatomy2019

Scaling of cardiac morphology is interrupted by birth in the developing sheep Ovis aries.

Edward P Snelling, Roger S Seymour, Dino A Giussani, Andrea Fuller, Shane K Maloney, Anthony P Farrell, Duncan Mitchell, Keith P George, Edward M Dzialowski, Sonnet S Jonker and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of anatomy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. The "fire of life cycles": age-specific metabolic scaling within and among species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 6 countries.

Edward P SnellingBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.ORCID 0000-0002-8985-8737
Roger S SeymourSchool of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0002-3395-0059
Dino A GiussaniDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1308-1204
Andrea FullerBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.ORCID 0000-0001-6370-8151
Shane K MaloneyBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.ORCID 0000-0002-5878-2266
Anthony P FarrellDepartment of Zoology, University of British Columbia, Vancouver, BC, Canada.
Duncan MitchellBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.ORCID 0000-0001-8989-4773
Keith P GeorgeResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.ORCID 0000-0002-5119-6651
Edward M DzialowskiDevelopmental Integrative Biology Research Group, Department of Biological Sciences, University of North Texas, Denton, TX, USA.ORCID 0000-0002-0620-1431
Sonnet S JonkerKnight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-1097-2562
Tilaye WubeDepartment of Zoological Sciences, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia.ORCID 0000-0002-3751-9282
The University of Western Australia · AUUniversity of the Witwatersrand · ZAAddis Ababa University · ETLiverpool John Moores University · GBOregon Health & Science University · USThe University of Adelaide · AUUniversity of British Columbia · CAUniversity of Cambridge · GBUniversity of North Texas · US

Funding

Australian Research Council Discovery GrantClaude Leon Postdoctoral FellowshipFRC Individual Grant and Iris Ellen Hodges FundJournal of Experimental BiologySociety for Experimental Biology Travel Grant
6 · The paper itself

Abstract

Scaling of the heart across development can reveal the degree to which variation in cardiac morphology depends on body mass. In this study, we assessed the scaling of heart mass, left and right ventricular masses, and ventricular mass ratio, as a function of eviscerated body mass across fetal and postnatal development in Horro sheep Ovis aries (~50-fold body mass range; N = 21). Whole hearts were extracted from carcasses, cleaned, dissected into chambers and weighed. We found a biphasic relationship when heart mass was scaled against body mass, with a conspicuous 'breakpoint' around the time of birth, manifest not by a change in the scaling exponent (slope), but rather a jump in the elevation. Fetal heart mass (g) increased with eviscerated body mass (M

Indexed as

HeartSheepAnimalsBody SizeFetal DevelopmentMammalsMorphogenesisallometrybiphasiccardiacfetalmorphogenesisontogeny

Identifiers

PMID30993709
PMCPMC6579936
OpenAlexW2937797169

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.