ArticleJournal of the American Society for Mass Spectrometry2019
Fragmentation of Multi-charged Derivatized Lysine Using Nanospray CID Tandem Mass Spectrometry.
Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Analysis of endogenous metabolites using multifunctional derivatization and capillary RPLC-MS.Analytical methods : advancing methods and applications · 2022Article
- Isomeric Differentiation and Acidic Metabolite Identification by Piperidine-Based Tagging, LC-MS/MS, and Understanding of the Dissociation Chemistries.Analytical chemistry · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We demonstrate increasing the charge state of small molecules using derivatized lysine as our model system. Lysine is chemically tagged with three tertiary amines which enables efficient production of highly charged analytes. A +3 charge state is obtained from direct infusion nanoelectrospray conditions. Collisional activation of the +3 derivatized lysine yielded structurally informative product ions corresponding to cleavages across the analyte backbone and within the proton affinity tags. This suggests a role for multi-charging of metabolites in both targeted MRM analyses and untargeted analyses to help identify novel metabolites. Density functional calculations aid peak assignment and rationalization of structure-property relationships. Graphical Abstract.
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Registered trials
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