ArticleMolecular biology reports2019
Isolation and screening of extracellular anticancer enzymes from halophilic and halotolerant bacteria from different saline environments in Iran.
Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 49 citations in OpenAlex.
- In Silico Characterization and Molecular Docking of the L-Arginase Gene From Alcaligenes aquatilis BC2.Biotechnology and applied biochemistry · 2026Article
- Deciphering the Genomic Traits of Multi-Enterocin-ProducingMicroorganisms · 2025Article
- Dynamics of the intratumoural microbiome across malignant transformation and treatment in breast cancer.Clinical and translational medicine · 2025Article
- Pharmaceutical applications of halophilic enzymes.Heliyon · 2025Review
- L-glutaminase synthesis by Klebsiella pneumoniae (AS KP 23) isolated from clinical strain, and its efficacy against human hepatocellular and breast cancer cell lines.BMC microbiology · 2025Article
- Production of extracellular L-arginase by Alcaligenes aquatilis BC2 isolated from soda lakes (Lake Chitu) of Ethiopia.Journal of industrial microbiology & biotechnology · 2024Article
- One-step purification and characterization of a haloprotease from Micrococcus sp. PC7 for the production of protein hydrolysates from Andean legumes.Archives of microbiology · 2024Article
- Characterization of a Type II L-Asparaginase from the HalotolerantLife (Basel, Switzerland) · 2023Article
- Simultaneous Production of Antibacterial Protein and Lipopeptides in Bacillus tequilensis, Detected by MALDI-TOF and GC Mass Analyses.Probiotics and antimicrobial proteins · 2023Article
- The Evaluation of Clinical Signs and Symptoms of Malignant Tumors Involving the Maxillary Sinus: Recommendation of an Examination Sieve and Risk Alarm Score.Healthcare (Basel, Switzerland) · 2023Article
- Review
- L-Glutaminase Synthesis by MarineMolecules (Basel, Switzerland) · 2021Article
- Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine.Marine drugs · 2019Review
- Interactions Between Oral Microbiota and Cancers in the Aging Community: A Narrative Review.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It was confirmed that several enzymes have anti-cancer activity. The enzymes L-asparaginase, L-glutaminase, and L-arginase were chosen according to amino acids starvation in cancer cells and screened in halophilic and halotolerant bacteria, given probably less immunological reactions of halophilic or halotolerant enzymes in patients. Out of 110 halophilic and halotolerant strains, isolated from different saline environments in Iran and screened, some could produce a variety of anticancer enzymes. A total of 29, 4, and 2 strains produced L-asparaginase, L-glutaminase, and L-arginase, respectively. According to the phenotypic characteristics and partial 16S rRNA gene sequence analysis, the positive strains-strains with the ability to produce these anticancer enzymes-were identified as the members of the genera: Bacillus, Dietzia, Halobacillus, Rhodococcus, Paenibacillus and Planococcus as Gram-positive bacteria and Pseudomonas, Marinobacter, Halomonas, Idiomarina, Vibrio and Stappia as Gram-negative bacteria. The production of anticancer enzymes was mostly observed in the rod-shaped Gram-negative isolates, particularly in the members of the genera Halomonas and Marinobacter. Most of the enzymes were produced in the stationary phase of growth and the maximum enzyme activity was experienced in strain GBPx3 (Vibrio sp.) for L-asparaginase at 1.0 IU/ml, strain R
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