ArticleFolia microbiologica2019
Antibacterial activity and mechanism of lactobionic acid against Staphylococcus aureus.
Article in Folia microbiologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Production of Biodegradable Film Containing Wheat Leaf Fiber and Protein Isolate, Reinforced With Encapsulated Silver Oxide Nanocomposite, as a Color Indicator for Monitoring the Spoilage of Minced Chicken Meat.Food science & nutrition · 2026Article
- From acidification to multi-targeted cellular modulation: dual impact of hydroxy acids on the skin microbiota and the epidermal barrier.Frontiers in cellular and infection microbiology · 2026Review
- Natural Antimicrobial Compounds as Promising Preservatives: A Look at an Old Problem from New Perspectives.Molecules (Basel, Switzerland) · 2024Review
- Antibacterial Activity and Mechanism ofInternational journal of molecular sciences · 2024Article
- Electrospun nanofibers incorporating lactobionic acid as novel active packaging materials: biological activities and toxicological evaluation.Discover nano · 2024Article
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- Synergistic antimicrobial system based on nisin and α-hydroxy organic acids.Archives of microbiology · 2023Article
- Multi-Enzymatic Synthesis of Lactobionic Acid Using Wood-Degrading Enzymes Produced by White Rot Fungi.Metabolites · 2023Article
- The antibacterial activity of berberine againstFrontiers in microbiology · 2023Article
- Correlation Analysis between GlpQ-Regulated Degradation of Wall Teichoic Acid and Biofilm Formation Triggered by Lactobionic Acid inFoods (Basel, Switzerland) · 2022Article
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- Inactivation ofFrontiers in microbiology · 2022Article
- Enhanced Antibacterial Potential of Amoxicillin againstAntibiotics (Basel, Switzerland) · 2021Article
- Antibacterial activity and mechanism of three isomeric terpineols of Cinnamomum longepaniculatum leaf oil.Folia microbiologica · 2021Article
- Berberine Damages the Cell Surface of Methicillin-ResistantFrontiers in microbiology · 2020Article
- Antimicrobial Carvacrol Incorporated in Flaxseed Gum-Sodium Alginate Active Films to Improve the Quality Attributes of Chinese Sea bass (Lateolabrax maculatus) during Cold Storage.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Lactobionic acid (LBA) is a newly identified natural polyhydroxy acid that is widely used in the food industry. In this study, the antibacterial effects and underlying mechanism of action of LBA against Staphylococcus aureus were investigated. LBA exhibited significant antibacterial activity against S. aureus with a determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 15 mg/mL and 50 mg/mL, respectively. The Growth curves indicated that LBA directly inhibited the growth of S. aureus. Moreover, LBA induced the leakage of alkaline phosphatase and nucleotides in the culture medium, indicating damage to the integrity of the S. aureus cell wall membrane, which was confirmed by transmission electron microscopy observations. The relative electric conductivity measurements indicated that LBA changed the cell membrane permeability. The preservation effect of LBA was evaluated by quantifying the total number of colonies, total volatile base nitrogen (TVB-N), and thiobarbituric acid reactive substances (TBARS). Overall, these results revealed that LBA exerts its antibacterial activity by breaking down the structure of the bacterial cell wall and membrane, thereby releasing the cellular contents as well as inhibiting protein synthesis, which ultimately lead to cell death. The total number of colonies, the TVB-N value, and the TBARS of cold fresh meat treated with preservatives were significantly lower than those of the control group (P < 0.05). With these antibacterial characteristics, LBA has potential to be used as a safe food additive in the food industry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.