Evidence map›Paper›PMID 30993489›Full record

ArticleThe AAPS journal2019

Fetal Concentrations of Budesonide and Fluticasone Propionate: a Study in Mice.

Syedsaoud Zaidi, Mong-Jen Chen, Daniel T Lee, Elsa Neubart, Pär Ewing, Anna Miller-Larsson, Günther Hochhaus

Abstract read
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In one paragraph

Article in The AAPS journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Syedsaoud ZaidiDepartments of Pharmaceutics, JHMHC, P3-33, University of Florida, 100494, Gainesville, Florida, 32610, USA.
Mong-Jen ChenDepartments of Pharmaceutics, JHMHC, P3-33, University of Florida, 100494, Gainesville, Florida, 32610, USA.
Daniel T LeeDepartments of Pharmaceutics, JHMHC, P3-33, University of Florida, 100494, Gainesville, Florida, 32610, USA.
Elsa NeubartDepartments of Pharmaceutics, JHMHC, P3-33, University of Florida, 100494, Gainesville, Florida, 32610, USA.
Pär EwingAstraZeneca Gothenburg, 431 83, Mölndal, Sweden.
Anna Miller-LarssonAstraZeneca Gothenburg, 431 83, Mölndal, Sweden.
Günther HochhausDepartments of Pharmaceutics, JHMHC, P3-33, University of Florida, 100494, Gainesville, Florida, 32610, USA. hochhaus@cop.ufl.edu.
University of Florida · USAstraZeneca (Sweden) · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study goal was to evaluate the transplacental transfer of two corticosteroids, budesonide (BUD) and fluticasone propionate (FP), in pregnant mice and investigate whether P-glycoprotein (P-gp) might be involved in reducing BUD transplacental transfer. Pregnant mice (N = 18) received intravenously either low (104.9 μg/kg) or high (1049 μg/kg) dose of [

Indexed as

AnimalsATP Binding Cassette Transporter, Subfamily B, Member 1BudesonideDose-Response Relationship, DrugFemaleFetusFluticasoneInjections, IntravenousMaternal ExposureMice, Inbred C57BLOrgan SpecificityPlacentaPregnancySubstrate SpecificityATP Binding Cassette Transporter, Subfamily B, Member 1BudesonideFluticasonebudesonidefluticasone propionateP-gpplacental drug transporters

Identifiers

PMID30993489
OpenAlexW2940104653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.