Evidence map›Paper›PMID 30993458›Full record

ArticleInternational journal of colorectal disease2019

Systemic inflammatory response predicts oncological outcomes in patients undergoing elective surgery for mismatch repair-deficient colorectal cancer.

Marta Climent, Éanna J Ryan, Áine Stakelum, Yi Ling Khaw, Ben Creavin, Angus Lloyd, Dalal Alhassan, Helen M Mohan, Rory Kennelly, Kieran Sheahan and 1 more

Abstract read
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In one paragraph

Article in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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  12. Old and New Blood Markers in Human Colorectal Cancer.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Marta ClimentCentre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland. martacliment@gmail.com.
Éanna J RyanCentre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Áine StakelumCentre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Yi Ling KhawDepartment of Histopathology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Ben CreavinCentre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Angus LloydSchool of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.
Dalal AlhassanSchool of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.
Helen M MohanCentre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Rory KennellyCentre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Kieran SheahanDepartment of Histopathology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Des C WinterCentre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
St. Vincent's University Hospital · IEUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA variety of inflammatory scoring systems and their prognostic value have been reported in many solid organ cancers. This study aimed to examine the association between the systemic and local inflammatory responses, and oncological outcomes in patients undergoing elective surgery for mismatch repair-deficient (dMMR) phenotype colorectal cancer (CRC). MATERIALS AND

methodsConsecutive patients undergoing resection for dMMR CRC were identified from a prospectively maintained database and compared with a cohort of patients with proficient mismatch repair system tumours. Systemic inflammatory response was assessed by the modified Glasgow prognostic score (mGPS), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, lymphocyte-monocyte ratio, C-reactive protein/albumin ratio, prognostic index and prognostic nutritional index. Local inflammatory response was defined by the presence of tumour infiltrating lymphocytes, tumour infiltrating neutrophils, plasma cells or macrophages at the invasive front. The inflammatory infiltrate was assessed using the Klintrup-Mäkinen (KM) score.

resultsOn univariable analysis, preoperative NLR ≥ 5 (hazard ratio [HR] 2.5; 95% confidence interval [CI] 1.25-5.19; p = 0.007) and mGPS (HR 1.6; 95% CI 1.1-2.6; p = 0.03) predicted worse overall survival, but only NLR was associated with greater recurrence (HR 3.6; 95% CI 1.5-8.8; p = 0.004). Increased local inflammatory response, as measured by KM score (HR 0.31; 95% CI 0.1-0.7; p = 0.009) and the presence of macrophages in the peritumoral infiltrate (HR 0.17; 95% CI 0.07-0.3; p < 0.001), was associated with better outcomes. NLR was the only independent prognostic factor of overall and disease-free survival.

conclusionSystemic inflammatory response predicts oncological outcomes in CRC patients, but only NLR has prognostic value in the dMMR group.

Indexed as

DNA Mismatch RepairAgedBiomarkersCohort StudiesColorectal NeoplasmsDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMultivariate AnalysisSystemic Inflammatory Response SyndromeTreatment OutcomeBiomarkersColorectal cancerLocal inflammatory responseNeutrophil–lymphocyte ratioPrognostic markersPrognostic scoresSystemic inflammatory response

Identifiers

PMID30993458
OpenAlexW2938098313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.