Observational studyHeart and vessels2019
History of gastroesophageal reflux disease in patients with suspected coronary artery disease.
Observational study in Heart and vessels, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Mapping Gastroesophageal Reflux Disease and Coronary Artery Disease: A Comprehensive Analysis of Multivariable Mendelian Randomization and Shared Genetic Etiology.Clinical cardiology · 2025Pooled it
- Sensitive detection of atherosclerotic coronary artery disease by a novel index of pressure-area relationship of the brachial artery.Heart and vessels · 2025Article
- Real-world analysis of characteristics and guideline adherence of antiplatelet drugs prescriptions among patients with coronary artery disease and its comorbidities: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Review
- Gastroesophageal reflux disease influences blood pressure components, lipid profile and cardiovascular diseases: Evidence from a Mendelian randomization study.Journal of translational internal medicine · 2024Article
- Factors Contributing to Coronary Microvascular Dysfunction in Patients with Angina and Non-Obstructive Coronary Artery Disease.Journal of cardiovascular development and disease · 2024Article
- Heartburn's Hidden Impact: A Narrative Review Exploring Gastroesophageal Reflux Disease (GERD) as a Cardiovascular Disease Risk Factor.Journal of clinical medicine · 2023Review
- Which Coronary Artery Should Be Preferred for Starting the Coronary Spasm Provocation Test?Life (Basel, Switzerland) · 2023Article
- Frequency and Clinical Impact of Family History of Coronary Artery Disease in Patients with Vasospastic Angina.Journal of cardiovascular development and disease · 2023Article
- Vasospastic angina in women: Clinical backgrounds and prognoses of patients younger than and older than 60 years.World journal of cardiology · 2023Article
- Does the intracoronary pressure differ according to two types (diffuse or focal) of coronary spasm?World journal of cardiology · 2023Article
- Clinical Characteristics and Prognosis of Patients with Vasospastic Angina Subjected to the Spasm Provocation Test and the Unavoidable Use of Nitroglycerin.Journal of cardiovascular development and disease · 2023Article
- Acute myocardial infarction followed by radiofrequency therapy for gastroesophageal reflux disease in a man: A case report.Clinical case reports · 2022Article
- The Impact of Myocardial Bridging on the Coronary Functional Test in Patients with Ischaemia with Non-Obstructive Coronary Artery Disease.Life (Basel, Switzerland) · 2022Article
- Clinical Characteristics and Prognosis of Patients with Multi-Vessel Coronary Spasm in Comparison with Those in Patients with Single-Vessel Coronary Spasm.Journal of cardiovascular development and disease · 2022Article
- Article
- Coronary Microvascular Vasodilatory Function: Related Clinical Features and Differences According to the Different Coronary Arteries and Types of Coronary Spasm.Journal of clinical medicine · 2021Article
- Intracoronary Thrombogenicity in Patients with Vasospastic Angina: An Observation Using Coronary Angioscopy.Diagnostics (Basel, Switzerland) · 2021Article
- Clinical significance of prolonged chest pain in vasospastic angina.World journal of cardiology · 2020Article
- General internists of experience suspected variant angina as gastroesophageal reflux diseases in two cases: Heart burn may be related to coronary spasm.Journal of cardiology cases · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that patients with gastroesophageal reflux disease (GERD) experience GERD-related chest pain, but little is known about the relationship between GERD and coronary artery disease (CAD). We evaluated medical history of GERD in patients with suspected CAD and its association with types of CAD. We enrolled 236 patients who underwent coronary angiography (CAG). We assessed past medical history of each patient, making note of esophageal or stomach diseases such as GERD including reflux esophagitis and non-erosive reflux disease. The patients were divided into the following three subgroups based on the CAG results. Group I, patients with o-CAD (> 50% stenosis with ischemic findings, n = 141); Group II, patients with vasospastic angina (VSA, with positive spasm provocation test without organic coronary stenosis, n = 52); and Group III, patients without organic coronary stenosis or VSA (n = 43). Group I included more men than women (p < 0.001) and the frequencies of smoking, lipid disorders, and diabetes mellitus in this group were higher than those in the other groups (p < 0.01). The frequency of medical history of GERD was significantly higher in Group II (21%) than in Group I (3%) or Group III (7%, p < 0.0001). Logistic regression analysis showed that a medical history of GERD (OR 7.8; p < 0.01) was one of the factors associated with the presence of VSA. Our findings showed that a medical history of GERD was frequently observed in approximately one-fifth of patients with VSA, indicating that VSA may be present in patients with chest pain and a medical history of GERD.
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