Evidence map›Paper›PMID 30993425›Full record

ReviewWorld journal of urology2019

Role of MRI in planning radical prostatectomy: what is the added value?

Jose Marenco, Clement Orczyk, Tom Collins, Caroline Moore, Mark Emberton

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jose MarencoUniversity College London Hospital, NHS Foundation Trust, 47 Wimpole Street, Marylebone, London, W1G 8SE, UK. jlmarencoj@gmail.com.ORCID http://orcid.org/0000-0001-5724-6245
Clement OrczykUniversity College London Hospital, NHS Foundation Trust, 47 Wimpole Street, Marylebone, London, W1G 8SE, UK.
Tom CollinsUniversity College London Hospital, NHS Foundation Trust, 47 Wimpole Street, Marylebone, London, W1G 8SE, UK.
Caroline MooreUniversity College London Hospital, NHS Foundation Trust, 47 Wimpole Street, Marylebone, London, W1G 8SE, UK.
Mark EmbertonUniversity College London Hospital, NHS Foundation Trust, 47 Wimpole Street, Marylebone, London, W1G 8SE, UK.

Funding

Medical Research Council MR/M009092/1
6 · The paper itself

Abstract

introductionThe goal of radical prostatectomy is to eradicate oncological disease while achieving the best possible functional outcomes. In this regard, nerve sparing offers a greater chance of recovering potency after surgery. Accurately locating prostate cancer foci is instrumental for identifying good candidates for this approach whilst maintaining safe oncological margins. In addition to this, the length of membranous urethra is an independent predictor of time to, and extent of, continence recovery. The introduction of Mp-MRI allows visualising malignant tissue within the prostate gland, which could lead to image-directed surgery planning as with other solid-organ cancers such as kidney, pancreas, breast or testes.

methodsA narrative review of the available literature was performed.

resultsMp-MRI demonstrated moderate sensitivity and high specificity to detect extra-capsular extension, seminal vesicle involvement or T3 stage. Measurements of membranous urethral length have shown to be useful in predicting probability of achieving continence after surgery. Furthermore, image-guided surgery has shown to be accurate to determine surgical planes to safely preserve neurovascular bundles.

conclusionThe use of Mp-MRI for pre-surgical planning introduces a new scenario where the previously homogeneous radical prostatectomy can be tailored to suit patient and tumour features. This has the potential to improve functional outcomes whilst not compromising on surgical margins. Moreover, the introduction of Mp-MRI increases the ability to predict functional outcomes after surgery and allows for a more accurate local staging. This in turn provides more information to both patients and clinicians in the decision-making process regarding treatment.

Indexed as

Multiparametric Magnetic Resonance ImagingHumansMagnetic Resonance ImagingMaleOrgan Sparing TreatmentsPeripheral NervesProstatectomyProstatic NeoplasmsSurgery, Computer-AssistedMRIProstate cancerRadical prostatectomy

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.