Evidence map›Paper›PMID 30993423›Full record

ArticleInternational archives of occupational and environmental health2019

Association between CYP2E1 and GOT2 gene polymorphisms and susceptibility and low-dose N,N-dimethylformamide occupational exposure-induced liver injury.

Haiyue Jiang, Xiaoyue Zhang, Jiayang Shen, Yu Zhang, Yiyang Gu, Tian Tian, Minjie Chu, Xun Zhuang, Yulong Lian

Abstract read
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In one paragraph

Article in International archives of occupational and environmental health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Haiyue JiangDivision of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Se Yuan Road, No. 9, Nantong, 226019, Jiangsu, China.
Xiaoyue ZhangDivision of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Se Yuan Road, No. 9, Nantong, 226019, Jiangsu, China.
Jiayang ShenDivision of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Se Yuan Road, No. 9, Nantong, 226019, Jiangsu, China.
Yu ZhangDivision of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Se Yuan Road, No. 9, Nantong, 226019, Jiangsu, China.
Yiyang GuJiaxing Maternal and Child Health Hospital, Jiaxing, Zhejiang, China.
Tian TianDivision of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Se Yuan Road, No. 9, Nantong, 226019, Jiangsu, China.
Minjie ChuDivision of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Se Yuan Road, No. 9, Nantong, 226019, Jiangsu, China.
Xun ZhuangDivision of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Se Yuan Road, No. 9, Nantong, 226019, Jiangsu, China.
Yulong LianDivision of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Se Yuan Road, No. 9, Nantong, 226019, Jiangsu, China. lianyulong444@163.com.
Nantong University · CNFirst Hospital of Jiaxing · CN

Funding

National Natural Science Foundation of China 81260424National Natural Science Foundation of China 81703297Natural Science Foundation of Jiangsu Province, China BK20171256Science and Technology Program of Nantong City MS12017014-6
6 · The paper itself

Abstract

objectiveTo investigate the effects of the interactions between the CYP2E1 and GOT2 gene polymorphisms and N,N-dimethylformamide (DMF) on liver injury.

methodsA total of 672 DMF-exposed workers were randomly selected from two synthetic leather enterprises in Suzhou, China, for follow-up in a cohort study. Information on exposure to DMF in the air was collected through a fixed-point air sampler in the worker's breathing zone. The subjects were assessed every year during the period of 2010-2015, they underwent occupational health examinations. Alanine aminotransferase and aspartate aminotransferase levels were measured. Peripheral blood was collected and DNA was extracted. The genotypes rs2031920, rs3813867 and rs6413432 of the CYP2E1 gene and rs7204324 of the GOT2 gene were detected by PCR, and analyzed using the Chi-square test and logistic regression analysis.

resultsWorkers exposed to a high cumulative dose of DMF were significantly more likely than low-exposed workers to develop liver injury. No association was observed between rs2031920, rs3813867 and rs6413432 of the CYP2E1 gene and DMF-induced liver damage. However, the A allele of rs7204324 on the GOT2 gene may be a risk factor for susceptibility to DMF-induced liver injury.

conclusionPolymorphisms of rs7204324 on GOT2 may play an important role in susceptibility to liver injury following exposure to DMF.

Indexed as

AdultAir Pollutants, OccupationalAspartate AminotransferasesChemical and Drug Induced Liver Injury, ChronicChinaCohort StudiesCytochrome P-450 CYP2E1DimethylformamideEnvironmental MonitoringFemaleHumansMaleMiddle AgedOccupational ExposurePolymorphism, GeneticRisk FactorsAir Pollutants, OccupationalAspartate AminotransferasesCytochrome P-450 CYP2E1DimethylformamideCYP2E1GOT2Liver injuryN,N-DimethylformamideOccupational exposure

Identifiers

PMID30993423
OpenAlexW2939926939

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.