ArticleCurrent genetics2019
The Bax inhibitor UvBI-1, a negative regulator of mycelial growth and conidiation, mediates stress response and is critical for pathogenicity of the rice false smut fungus Ustilaginoidea virens.
Article in Current genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 42 citations in OpenAlex.
- The Basic Helix-Loop-Helix Transcription Factors UvBhlh1 and UvBhlh6 Coordinate Virulence in the Rice False Smut Fungus Ustilaginoidea virens.Molecular plant pathology · 2026Article
- Bax Inhibitor MoBi-1 Is Required for Conidiation, Pathogenicity, and Stress Responses inJournal of fungi (Basel, Switzerland) · 2025Article
- The Bacteria-Derived dsRNA Was Used for Spray-Induced Gene Silencing for Rice False Smut Control.Journal of agricultural and food chemistry · 2024Article
- The Ras GTPase-activating protein UvGap1 orchestrates conidiogenesis and pathogenesis in the rice false smut fungus Ustilaginoidea virens.Molecular plant pathology · 2024Article
- The Identification, Characterization, and Functional Analysis of the Sugar Transporter Gene Family of the Rice False Smut Pathogen,International journal of molecular sciences · 2024Article
- UvATG6 Interacts with BAX Inhibitor 1 Proteins and Plays Critical Roles in Growth, Conidiation, and Virulence inMicrobiology spectrum · 2023Article
- P3/P3N-PIPO of PVY interacting with BI-1 inhibits the degradation of NIb by ATG6 to facilitate virus replication inFrontiers in plant science · 2023Article
- The Adaptor Protein UvSte50 Governs Fungal Pathogenicity ofJournal of fungi (Basel, Switzerland) · 2022Article
- Genome-Wide Identification and Functional Analysis of the bZIP Transcription Factor Family in Rice Bakanae Disease Pathogen,International journal of molecular sciences · 2022Article
- A novel transcription factor UvCGBP1 regulates development and virulence of rice false smut fungusVirulence · 2021Article
- Genome-Wide Identification and Functional Characterization of CCHC-Type Zinc Finger Genes inJournal of fungi (Basel, Switzerland) · 2021Article
- Quantitative Proteomics Analysis Reveals the Function of the Putative Ester Cyclase UvEC1 in the Pathogenicity of the Rice False Smut FungusInternational journal of molecular sciences · 2021Article
- SUN-Family ProteinFrontiers in microbiology · 2021Article
- Two mating-type genes MAT1-1-1 and MAT1-1-2 with significant functions in conidiation, stress response, sexual development, and pathogenicity of rice false smut fungus Villosiclava virens.Current genetics · 2020Article
- UvAtg8-Mediated Autophagy Regulates Fungal Growth, Stress Responses, Conidiation, and Pathogenesis in Ustilaginoidea virens.Rice (New York, N.Y.) · 2020Article
- The Conserved Effector UvHrip1 interacts with OsHGW, and Infection ofInternational journal of molecular sciences · 2020Article
- Two protein kinases UvPmk1 and UvCDC2 with significant functions in conidiation, stress response and pathogenicity of rice false smut fungus Ustilaginoidea virens.Current genetics · 2020Article
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11 authors at 2 institutions in 2 countries.
Funding
Abstract
Bax inhibitor-1 (BI-1), an evolutionarily conserved protein, is a suppressor of cell death induced by the proapoptotic protein Bax and is involved in the response to biotic and abiotic stress in animals, plants and yeast. Rice false smut caused by Ustilaginoidea virens is one of the destructive rice diseases worldwide. Although BI-1 proteins are widely distributed across filamentous fungi, few of them are functionally characterized. In this study, we identified a BI-1 protein in U. virens, UvBI-1, which contains a predicted Bax inhibitor-1-like family domain and could suppress the cell death induced by Bax. By co-transformation of the CRISPR/Cas9 construct along with donor DNA fragment containing the hygromycin resistance gene, we successfully generated Uvbi-1 deletion mutants. The UvBI-1 deletion showed an increase in mycelia vegetative growth and conidiation, suggesting this gene acts as a negative regulator of the growth and conidiation. In addition, the Uvbi-1 mutants exhibited higher sensitivity to osmotic and salt stress, hydrogen peroxide stress, and cell wall or membrane stress than the wild-type strain. Furthermore, UvBI-1 deletion was found to cause increased production of secondary metabolites and loss of pathogenicity of U. virens. Taken together, our results demonstrate that UvBI-1 plays a negative role in mycelial growth and conidiation, and is critical for stress tolerance, cell wall integrity, secondary metabolites production and pathogenicity of U. virens. Therefore, this study provides new evidence on the conserved function of BI-1 among fungal organisms and other species.
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