Evidence map›Paper›PMID 30993378›Full record

ArticleArchives of toxicology2019

1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence.

Melanie Wiesner-Reinhold, Gitte Barknowitz, Simone Florian, Inga Mewis, Fabian Schumacher, Monika Schreiner, Hansruedi Glatt

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Quo vadis blood protein adductomics?Archives of toxicology · 2022
    Review
  4. The Role ofMolecules (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Melanie Wiesner-ReinholdLeibniz Institute of Vegetable and Ornamental Crops e.V., Theodor-Echtermeyer-Weg 1, 14979, Grossbeeren, Germany.
Gitte BarknowitzDepartment of Nutritional Toxicology, Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.
Simone FlorianDepartment of Nutritional Toxicology, Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.
Inga MewisLeibniz Institute of Vegetable and Ornamental Crops e.V., Theodor-Echtermeyer-Weg 1, 14979, Grossbeeren, Germany.
Fabian SchumacherDepartment of Nutritional Toxicology, Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.
Monika SchreinerLeibniz Institute of Vegetable and Ornamental Crops e.V., Theodor-Echtermeyer-Weg 1, 14979, Grossbeeren, Germany.
Hansruedi GlattDepartment of Nutritional Toxicology, Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany. glatt@dife.de.ORCID http://orcid.org/0000-0001-6053-0562
German Institute of Human Nutrition · DELeibniz Institute of Vegetable and Ornamental Crops · DEFederal Institute for Risk Assessment · DEHumboldt-Universität zu Berlin · DEUniversity of Potsdam · DE

Funding

Bundesministerium für Bildung und Forschung 0315370D
6 · The paper itself

Abstract

We previously showed that purified 1-methoxy-3-indolylmethyl (1-MIM) glucosinolate, a secondary plant metabolite in Brassica species, is mutagenic in various in vitro systems and forms DNA and protein adducts in mouse models. In the present study, we administered 1-MIM glucosinolate in a natural matrix to mice, by feeding a diet containing pak choi powder and extract. Groups of animals were killed after 1, 2, 4 and 8 days of pak choi diet, directly or, in the case of the 8-day treatment, after 0, 8 and 16 days of recovery with pak choi-free diet. DNA adducts [N

Indexed as

DietAnimalsArylsulfotransferaseBlood ProteinsBody WeightBrassicaChromatography, High Pressure LiquidDNA AdductsGlucosinolatesHemoglobinsIndolesMaleMass SpectrometryMiceSerum AlbuminTandem Mass Spectrometry1-methoxy-3-indolylmethyl glucosinolate1-methoxy-3-indolylmethylglucosinolateArylsulfotransferaseBlood ProteinsDNA AdductsGlucosinolatesHemoglobinsIndolesSerum AlbuminSult1a1 protein, mouse1-Methoxy-3-indolylmethyl glucosinolateBlood protein adductsDNA adductsNeoglucobrassicinPak choi

Identifiers

PMID30993378
OpenAlexW2938509207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.