ArticleEuropean heart journal. Cardiovascular Imaging2019
Focal scar and diffuse myocardial fibrosis are independent imaging markers in repaired tetralogy of Fallot.
Article in European heart journal. Cardiovascular Imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- The relationship between myocardial and hepatic T1 relaxometry on cardiovascular magnetic resonance imaging and clinical outcomes late after tetralogy of Fallot repair.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026Article
- Detecting early structural and functional myocardial alterations in patients with repaired tetralogy of fallot: a prospective MRI study.Scientific reports · 2026Article
- From repair to right heart failure: Understanding the evolving landscape in tetralogy of fallot.Heart failure reviews · 2025Review
- Burden of diffuse myocardial fibrosis assessed by cardiac magnetic resonance in repaired tetralogy of Fallot: A systematic review and meta-analysis.International journal of cardiology. Congenital heart disease · 2025Article
- T1 mapping of the right ventricle in congenital heart disease: a focus on pediatrics.Pediatric radiology · 2025Review
- Successful Management of Ventricular Tachycardia in an Adult Case of Unrepaired Pulmonary Atresia With Ventricular Septal Defect: A Case Report.CJC pediatric and congenital heart disease · 2025Article
- Right ventricular dysfunction following tetralogy of Fallot correction: anatomical determinants and therapeutic strategies.International journal of surgery (London, England) · 2025Review
- Dual inhibition of TGFβ and PDGF improves RV remodeling and function in response to RV pressure or volume-loading.Physiological reports · 2025Article
- Cardiovascular magnetic resonance in Tetralogy of Fallot-state of the art.Cardiovascular diagnosis and therapy · 2025Review
- Assessment of right ventricular diastolic function in pediatric patients with repaired tetralogy of Fallot by cardiovascular magnetic resonance and echocardiography.European radiology · 2024Article
- Repaired Tetralogy of Fallot: Have We Understood the Right Timing of PVR?Journal of clinical medicine · 2024Review
- Disease severity, arrhythmogenesis, and fibrosis are related to longer action potentials in tetralogy of Fallot.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Use of Cardiovascular Magnetic Resonance for Risk Stratification in Repaired Tetralogy of Fallot.CJC pediatric and congenital heart disease · 2023Review
- First experience with real-time magnetic resonance imaging-based investigation of respiratory influence on cardiac function in pediatric congenital heart disease patients with chronic right ventricular volume overload.Pediatric radiology · 2023Article
- Tetralogy of Fallot Across the Lifespan: A Focus on the Right Ventricle.CJC pediatric and congenital heart disease · 2023Review
- Differentiation between mild and severe myocarditis using multiparametric cardiac magnetic resonance.Radiology case reports · 2023Article
- Myocardial Fibrosis in Congenital Heart Disease and the Role of MRI.Radiology. Cardiothoracic imaging · 2023Review
- Biopsy-detected myocardial fibrosis predicts adverse cardiac events after pulmonary valve replacement in patients with repaired tetralogy of Fallot.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Right Ventricular Fibrosis After Tetralogy of Fallot Repair: Can Pulmonary Valve Replacement Make a Difference?JACC. Basic to translational science · 2023Article
- Histopathological validation of semi-automated myocardial scar quantification techniques for dark-blood late gadolinium enhancement magnetic resonance imaging.European heart journal. Cardiovascular Imaging · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo identify the correlates of focal scar and diffuse fibrosis in patients with history of tetralogy of Fallot (TOF) repair. METHODS AND
resultsConsecutive patients with prior TOF repair underwent electrocardiogram, 24-h Holter, transthoracic echocardiography, exercise testing, and cardiac magnetic resonance (CMR) including cine imaging to assess ventricular volumes and ejection fraction, T1 mapping to assess left ventricular (LV) and right ventricular (RV) diffuse fibrosis, and free-breathing late gadolinium-enhanced imaging to quantify scar area at high spatial resolution. Structural imaging data were related to clinical characteristics and functional imaging markers. Cine and T1 mapping results were compared with 40 age- and sex-matched controls. One hundred and three patients were enrolled (age 28 ± 15 years, 36% women), including 36 with prior pulmonary valve replacement (PVR). Compared with controls, TOF showed lower LV ejection fraction (LVEF) and RV ejection fraction (RVEF), and higher RV volume, RV wall thickness, and native T1 and extracellular volume values on both ventricles. In TOF, scar area related to LVEF and RVEF, while LV and RV native T1 related to RV dilatation. On multivariable analysis, scar area and LV native T1 were independent correlates of ventricular arrhythmia, while RVEF was not. Patients with history of PVR showed larger scars on RV outflow tract but shorter LV and RV native T1.
conclusionFocal scar and biventricular diffuse fibrosis can be characterized on CMR after TOF repair. Scar size relates to systolic dysfunction, and diffuse fibrosis to RV dilatation. Both independently relate to ventricular arrhythmias. The finding of shorter T1 after PVR suggests that diffuse fibrosis may reverse with therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.