Evidence map›Paper›PMID 30993251›Full record

ArticlePathogens & immunity2019

The Microbiome of Temporal Arteries.

Gary S Hoffman, Ted M Getz, Roshan Padmanabhan, Alexandra Villa-Forte, Alison H Clifford, Pauline Funchain, Madhav Sankunny, Julian D Perry, Alexander Blandford, Gregory Kosmorsky and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Pathogens & immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. [EJNMMI research · 2023
    Article
  10. Article
  11. Review
  12. Review
  13. Age as a risk factor in vasculitis.Seminars in immunopathology · 2022
    Review
  14. Findings on the Relationship Between Intestinal Microbiome and Vasculitis.Frontiers in cellular and infection microbiology · 2022
    Review
  15. Review
  16. Article
  17. The microbiome in autoimmune rheumatic disease.Best practice & research. Clinical rheumatology · 2020
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Gary S HoffmanCenter for Vasculitis Care and Research; Department of Rheumatic and Immunologic Diseases; Cleveland Clinic; Cleveland, Ohio.
Ted M GetzGenomic Medicine Institute; Lerner Research Institute; Cleveland Clinic; Cleveland, Ohio.
Roshan PadmanabhanGenomic Medicine Institute; Lerner Research Institute; Cleveland Clinic; Cleveland, Ohio.
Alexandra Villa-ForteCenter for Vasculitis Care and Research; Department of Rheumatic and Immunologic Diseases; Cleveland Clinic; Cleveland, Ohio.
Alison H CliffordCenter for Vasculitis Care and Research; Department of Rheumatic and Immunologic Diseases; Cleveland Clinic; Cleveland, Ohio.
Pauline FunchainGenomic Medicine Institute; Lerner Research Institute; Cleveland Clinic; Cleveland, Ohio.
Madhav SankunnyGenomic Medicine Institute; Lerner Research Institute; Cleveland Clinic; Cleveland, Ohio.
Julian D PerryCole Eye Institute; Cleveland Clinic; Cleveland, Ohio.
Alexander BlandfordCole Eye Institute; Cleveland Clinic; Cleveland, Ohio.
Gregory KosmorskyCole Eye Institute; Cleveland Clinic; Cleveland, Ohio.
Lisa LystadCole Eye Institute; Cleveland Clinic; Cleveland, Ohio.
Leonard H CalabreseCenter for Vasculitis Care and Research; Department of Rheumatic and Immunologic Diseases; Cleveland Clinic; Cleveland, Ohio.
Charis EngGenomic Medicine Institute; Lerner Research Institute; Cleveland Clinic; Cleveland, Ohio.
Cleveland Clinic · US

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
NCATS NIH HHS UL1 TR000439
6 · The paper itself

Abstract

objectiveA role for microorganisms in giant cell arteritis (GCA) has long been suspected. We describe the microbiomes of temporal arteries from patients with GCA and controls.

methodsTemporal artery biopsies from patients suspected to have GCA were collected under aseptic conditions and snap-frozen. Fluorescence

resultsForty-seven patients, including 9 with biopsy-positive GCA, 15 with biopsy-negative GCA and 23 controls without GCA, were enrolled. FISH for bacterial DNA revealed signal in the arterial media. Beta, but not alpha, diversity differed between GCA and control temporal arteries (

conclusionTemporal arteries are not sterile, but rather are inhabited by a community of bacteria. We have demonstrated that there are microbiomic differences between GCA and non-GCA temporal arteries, but not between biopsy-positive and biopsy-negative GCA.

Indexed as

giant cell arteritismicrobiomevasculitis

Identifiers

PMID30993251
PMCPMC6423729
OpenAlexW2912937798

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.