SynthesisCommunications biology2019
Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 9 pooled it
9.0field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
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Who cites it
67 citing papers in PubMed, 9 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Meta-analysis of urinary metabolite GWAS studies identifies novel genome-wide significant loci.Scientific reports · 2025Pooled it
- Association between serum uric acid and prostate cancer risk in East Asian populations: a Mendelian randomization study.European journal of nutrition · 2023Pooled it
- Novel Insights into the Effects of Genetic Variants on Serum Urate Response to an Acute Fructose Challenge: A Pilot Study.Nutrients · 2022Pooled it
- Genome-wide meta-analysis revealed several genetic loci associated with serum uric acid levels in Korean population: an analysis of Korea Biobank data.Journal of human genetics · 2022Pooled it
- Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.Human cell · 2021Pooled it
- Polygenic analysis of the effect of common and low-frequency genetic variants on serum uric acid levels in Korean individuals.Scientific reports · 2020Pooled it
- Subtype-specific gout susceptibility loci and enrichment of selection pressure onAnnals of the rheumatic diseases · 2020Pooled it
- A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population.Human cell · 2020Pooled it
- Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.Annals of the rheumatic diseases · 2019Pooled it
- Triangulating Evidence on Serum Uric Acid and Cancer Risk: Consistent Inverse Associations With Lung Cancer.Cancer science · 2026Article
- Effects of ABCG2 dysfunction on hyperuricemia progression in premenopausal and postmenopausal women.Human cell · 2026Article
- Multi-omics insights into uric acid metabolism in cardiometabolic disease: from genetics to metabolomics.Biomedical journal · 2026Review
- Rare variant optimized GWAS with functional validation identifies causal architecture of kidney function in East Asian population.Scientific reports · 2026Article
- SLC52A1 is a neofunctionalized primate urate transporter enabling intestinal urate secretion.The Journal of biological chemistry · 2026Article
- Serum uric acid levels among children and adolescents in China: percentile reference values and national prevalence estimates of hyperuricemia.BMC medicine · 2026Article
- Article
- Distinct Characteristics of Patients with Gout and an Underweight or Normal Body Mass Index: A Single-Center Retrospective Cross-Sectional Study.Life (Basel, Switzerland) · 2025Article
- Sestrins: a new therapeutic target for endothelial dysfunction and cardiovascular disease prevention.Annals of medicine · 2025Review
- A Comprehensive Review of the Genetics of Dyslipidemias and Risk of Atherosclerotic Cardiovascular Disease.Nutrients · 2025Review
- Exploring the Role of Glycine Metabolism in Coronary Artery Disease: Insights from Human Genetics and Mouse Models.Nutrients · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
50 authors at 20 institutions in 3 countries.
Masahiro Nakatochi *1Data Science Division, Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, 466-8560 Japan.ORCID 0000-0002-1838-4837
Masahiro Kanai *Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045 Japan.ORCID 0000-0001-5165-4408
Akiyoshi Nakayama *5Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, 359-8513 Japan.
Asahi Hishida *7Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550 Japan.
Yusuke Kawamura *5Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, 359-8513 Japan.
Sahoko Ichihara9Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, 329-0498 Japan.
Masato AkiyamaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045 Japan.
Hiroaki Ikezaki11Department of General Internal Medicine, Kyushu University Hospital, Fukuoka, 812-8582 Japan.
Norihiro Furusyo11Department of General Internal Medicine, Kyushu University Hospital, Fukuoka, 812-8582 Japan.
Seiko Shimizu5Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, 359-8513 Japan.
Ken Yamamoto12Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, 830-0011 Japan.ORCID 0000-0002-1531-9685
Makoto Hirata13Laboratory of Genome Technology, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639 Japan.ORCID 0000-0002-9994-9958
Rieko Okada7Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550 Japan.ORCID 0000-0002-6206-2501
Sayo Kawai7Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550 Japan.ORCID 0000-0002-5156-4880
Makoto Kawaguchi5Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, 359-8513 Japan.
Yuichiro Nishida15Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, 849-8501 Japan.ORCID 0000-0003-2320-7234
Chisato Shimanoe15Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, 849-8501 Japan.
Rie Ibusuki16International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544 Japan.
Toshiro Takezaki16International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544 Japan.
Mayuko Nakajima5Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, 359-8513 Japan.
Mikiya Takao5Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, 359-8513 Japan.
Etsuko Ozaki18Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602-8566 Japan.
Daisuke Matsui18Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602-8566 Japan.
Takeshi Nishiyama19Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8602 Japan.
Sadao Suzuki19Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8602 Japan.
Naoyuki Takashima20Department of Health Science, Shiga University of Medical Science, Otsu, 520-2192 Japan.
Yoshikuni Kita21Department of Nursing, Tsuruga City College of Nursing, Fukui, 914-8501 Japan.ORCID 0000-0002-2366-1106
Kaori Endoh22Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, 422-8526 Japan.
Kiyonori Kuriki22Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, 422-8526 Japan.
Hirokazu Uemura23Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8503 Japan.ORCID 0000-0002-0443-4266
Kokichi Arisawa23Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8503 Japan.
Isao Oze24Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, 464-8681 Japan.ORCID 0000-0002-0762-1147
Keitaro Matsuo24Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, 464-8681 Japan.ORCID 0000-0003-1761-6314
Yohko Nakamura26Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, 260-8717 Japan.
Haruo Mikami26Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, 260-8717 Japan.
Takashi Tamura7Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550 Japan.
Hiroshi Nakashima27Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, 359-8513 Japan.
Takahiro Nakamura28Laboratory for Mathematics, National Defense Medical College, Tokorozawa, 359-8513 Japan.
Norihiro Kato29Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655 Japan.
Koichi Matsuda30Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, 108-8639 Japan.ORCID 0000-0001-7292-2686
Yoshinori Murakami31Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639 Japan.
Tatsuaki Matsubara32Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, 464-8651 Japan.
Mariko Naito7Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550 Japan.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045 Japan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045 Japan.ORCID 0000-0001-8748-5597
Nariyoshi Shinomiya5Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, 359-8513 Japan.
Mitsuhiro Yokota36Department of Genome Science, School of Dentistry, Aichi Gakuin University, Nagoya, 464-8651 Japan.
Kenji Wakai7Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550 Japan.
Yukinori OkadaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045 Japan.ORCID 0000-0002-0311-8472
Hirotaka Matsuo5Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, 359-8513 Japan.
Nagoya University · JPNational Defense Medical College · JPNational Defense Medical College Hospital · JPAichi Cancer Center · JPAichi Gakuin University · JPChiba Cancer Center · JPKagoshima University · JPKyoto Prefectural University of Medicine · JPKyushu University Hospital · JPNagoya City University · JPRIKEN Center for Integrative Medical Sciences · JPSaga University · JPThe University of Tokyo · JPTokushima University · JPUniversity of Shizuoka · JPAir Liquide (United Kingdom) · GBHarvard University · USHiroshima University · JPJichi Medical University · JPKurume University Medical Center · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci (
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyQuantitative Trait, HeritableQuantitative Trait LociAllelesComputational BiologyGenotypeGoutHumansJapanMolecular Sequence AnnotationPolymorphism, Single NucleotideUric AcidUric Acid
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