Evidence map›Paper›PMID 30993190›Full record

ArticleTransplantation direct2019

Differences in Gene Expression in Older Compared With Younger Kidney Transplant Recipients.

Joanna M Schaenman, Maura Rossetti, Erik Lum, Basmah Abdalla, Suphamai Bunnapradist, Thu-Phuong Pham, Gabriel Danovitch, Elaine F Reed, Steve Cole

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Joanna M SchaenmanDivision of Infectious Diseases, Department of Medicine, UCLA Immunogenetics Center, Los Angeles, CA.
Maura RossettiDepartment of Pathology and Laboratory Medicine, UCLA Immunogenetics Center, Los Angeles, CA.
Erik LumDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Basmah AbdallaDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Suphamai BunnapradistDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Thu-Phuong PhamDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Gabriel DanovitchDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Elaine F ReedDepartment of Pathology and Laboratory Medicine, UCLA Immunogenetics Center, Los Angeles, CA.
Steve ColeDivision of Hematology-Oncology, Department of Medicine, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA.
University of California, Los Angeles · USUCLA Medical Center · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Project 3: Mapping the Evolution of Chronic Transplant Injury in the Context of CMV InfectionU19AI128913 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REED, ELAINE F · 2017 to 2021
$11.2M
Systems Immunolobiology of Antibiotic-Persistent MRSA InfectionU01AI124319 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI YEAMAN, MICHAEL R · 2016 to 2020
$10.1M
Evaluation of T Cell Immune Function Impairment in Elderly Solid Organ Transplant RecipientsR03AG050946 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHAENMAN, JOANNA M · 2015 to 2016
$231k
NCATS NIH HHS UL1 TR001881NIAID NIH HHS U01 AI124319NIAID NIH HHS U19 AI128913NIA NIH HHS R03 AG050946
6 · The paper itself

Abstract

backgroundFor the growing numbers of older transplant patients, increased incidence of infection and death compared with younger patients may limit the many benefits provided by transplantation. However, little is known about age-associated immune dysfunction in the older transplant recipient.

methodsA cohort of 60 kidney transplant recipients, 23 older (≥ 60y) and 37 younger (30-59y), matched on antithymocyte induction and donor type (living vs deceased) was evaluated. Gene expression in peripheral blood mononuclear cells 3 months after kidney transplantation was analyzed to compare differences between older and younger patients.

resultsProinflammatory genes were upregulated in older kidney transplant patients, including cytokines IL1-β and IL-6. Downregulated genes were associated with B-cell and T-cell function, including CCR7 and CD27. Analysis of predicted transcription factor binding suggested an increase in proinflammatory transcription factor CCAAT/enhancer binding protein β-binding sites in older patients, whereas interferon regulatory factor 2 transcription factor binding sites were less prevalent.

conclusionsOlder kidney transplant recipients exhibited multiple differences in gene expression compared with younger patients, with upregulation of proinflammatory genes and downregulation of adaptive immune response genes. These findings may explain the mechanism of increased vulnerability to infection and malignancy observed in older transplant patients.

Identifiers

PMID30993190
PMCPMC6445656
OpenAlexW2924321382

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.