Evidence map›Paper›PMID 30993020›Full record

ArticleInternational journal of nephrology2019

Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients.

Nora A Khreba, Mostafa Abdelsalam, A M Wahab, Mohammed Sanad, Rania Elhelaly, Mohammed Adel, Ghada El-Kannishy

Abstract read
In one paragraph

Article in International journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Article
  5. Observational
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  14. Macrophage angiotensin ATAmerican journal of physiology. Renal physiology · 2023
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  18. Potential Biomarkers in Diagnosis of Renal Acanthamoebiasis.International journal of molecular sciences · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nora A KhrebaMansoura Nephrology and Dialysis Unit, Internal Medicine Department, Mansoura University, Egypt.
Mostafa AbdelsalamMansoura Nephrology and Dialysis Unit, Internal Medicine Department, Mansoura University, Egypt.ORCID 0000-0002-4682-2777
A M WahabMansoura Nephrology and Dialysis Unit, Internal Medicine Department, Mansoura University, Egypt.
Mohammed SanadCardiothoracic Surgery Department, Mansoura University, Egypt.
Rania ElhelalyClinical Pathology Department, Mansoura University, Egypt.
Mohammed AdelAnesthesia and Surgical Intensive Care, Mansoura University, Egypt.
Ghada El-KannishyMansoura Nephrology and Dialysis Unit, Internal Medicine Department, Mansoura University, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPostoperative acute kidney injury is associated with a higher mortality, a more complicated hospital course with longer hospital stay. Urinary kidney injury molecule 1 may play an important role as an early predictor of acute kidney injury post-cardiopulmonary in open heart surgery.

methodsWe evaluated 45 patients who underwent open heart surgery from January 2016 to June 2016. Both urinary kidney injury molecule 1 and serum creatinine were evaluated before operation and 3hs and 24hs after operation. Acute kidney injury was diagnosed according to Kidney Disease: Improving Global Outcomes, 2012 guidelines.

resultsIn this study, 27 patients developed acute kidney injury. The three hour-post-surgery urinary kidney injury molecule 1 was significantly higher in the acute kidney injury group (P<0.015) and, at the same time, we did not find any significant difference in the serum creatinine levels between the two groups.

conclusionAlthough serum creatinine is still the gold standard for diagnosis of acute kidney injury searching for other new markers is mandatory. Urinary kidney injury molecule 1 can be used as simple noninvasive and specific biomarker for early diagnosis of acute kidney injury.

Identifiers

PMID30993020
PMCPMC6434264

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.