Evidence map›Paper›PMID 30993014›Full record

ArticleCell death discovery2019

Sirt6-induced autophagy restricted TREM-1-mediated pyroptosis in ox-LDL-treated endothelial cells: relevance to prognostication of patients with acute myocardial infarction.

Ye Zi, Yao Yi-An, Ji Bing, Lai Yan, Tong Jing, Guan Chun-Yu, Ping Fan, Lin Hao, Tang Jia-Ni, Hou Han-Jin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. A Lipid Perspective on Regulated Pyroptosis.International journal of biological sciences · 2023
    Review
  13. Review
  14. Article
  15. The Molecular Pathways of Pyroptosis in Atherosclerosis.Frontiers in cell and developmental biology · 2022
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ye Zi *Department of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Yao Yi-An *Department of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Ji BingDepartment of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Lai YanDepartment of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Tong JingDepartment of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Guan Chun-YuDepartment of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Ping FanDepartment of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Lin HaoDepartment of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Tang Jia-NiDepartment of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Hou Han-JinDepartment of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Chen FeiDepartment of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Liu Xue-BoDepartment of Cardiology, Shanghai Tongji Hospital, Tongji University, Shanghai, China.
Tongji Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation mediated by myeloid cells trigger receptors 1 (TREM-1) is important for atherosclerosis development, while sirtuin 6 (Sirt6) levels decrease in atheroscleoritc plaque. Here we demonstrate that oxidatively modified low density lipoprotein (ox-LDL)-treated endothelial cells (ECs) exhibited increased TREM-1-mediated pyroptosis and decreased Sirt6-induced autophagy. We show that high sTREM-1 and low sSirt6 levels were independent predictors of boosted endothelial microparticles (EMPs) on admission, and were associated with increased risk for all-cause mortality and major adverse cardiovascular events (MACE) at median 24 months (interquartile range, 18-26) follow-up in acute myocardial infarction (AMI) patients. Additionally, blockage of Sirt6-induced autophagy led to augmented TREM-1-mediated pyroptosis, whereas Sirt6 overexpression attenuated ECs inflammation and pyroptosis following ox-LDL treatment. Our findings indicate that TREM-1 and in a reversed trend Sirt6 appeared to be markers of endothelial inflammation with potential for use in risk stratification.

Identifiers

PMID30993014
PMCPMC6461678
OpenAlexW2937213781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.