Evidence map›Paper›PMID 30992691›Full record

ArticleCancer cell international2019

RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin-proteasome pathway contributes to the reversion of ATRA resistance.

Wenzhe Yan, Ji Li, Yang Zhang, Yafei Yin, Zhao Cheng, Jiayi Wang, Guoyu Hu, Sufang Liu, Yewei Wang, Yunxiao Xu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Novel partners of USP6 gene in a spectrum of bone and soft tissue lesions.Virchows Archiv : an international journal of pathology · 2021
    Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Wenzhe Yan1Department of Hematology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.
Ji Li1Department of Hematology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.
Yang Zhang2Department of Oncology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.
Yafei YinDepartment of Hematology, Xiangtan Central Hospital, Changsha, 410011 Hunan China.
Zhao Cheng1Department of Hematology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.
Jiayi Wang4Department of Nephrology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.
Guoyu Hu5Department of Hematology, Zhuzhou No.1 Hospital, Zhuzhou, 410011 Hunan China.
Sufang Liu1Department of Hematology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.
Yewei Wang1Department of Hematology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.
Yunxiao Xu1Department of Hematology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.
Hongling Peng1Department of Hematology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.
Guangsen Zhang1Department of Hematology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.ORCID 0000-0002-3812-9892
Central South University · CNZhuzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsTo reveal the functional characteristics and regulating mechanism of the

resultWe confirmed resistance of GTF2I-RARA to ATRA. Compared with

conclusionOur results suggest that RNF8 is a key

Indexed as

APLGTF2I-RARAProteasome inhibitorRARARNF8

Identifiers

PMID30992691
PMCPMC6449960
OpenAlexW2942849572

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.