ArticleInternational journal of nanomedicine2019
Biomimetic hydroxyapatite nanocrystals are an active carrier for
Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Pooled it
- Isolation, Characterization, and In Vivo Evaluation Efficacy of Lytic Bacteriophage SEP1 AgainstViruses · 2026Article
- Review
- Bacteriophage cocktail LEC2-LEC10 for broad-spectrum control of pathogenic and uncharacterizedFrontiers in microbiology · 2025Article
- Antimicrobial Resistance and New Antimicrobial Agents, A Review of the Literature.Current medicinal chemistry · 2025Review
- Effect of the Biopolymer Carrier onBiomolecules · 2022Article
- Biomaterial-based delivery of antimicrobial therapies for the treatment of bacterial infections.Nature reviews. Materials · 2022Article
- Hydroxyapatite Nanoparticles in Drug Delivery: Physicochemistry and Applications.Pharmaceutics · 2021Review
- Lactoferrin, Quercetin, and Hydroxyapatite Act Synergistically againstInternational journal of molecular sciences · 2021Article
- Novel Biomimetic Human TLR2-Derived Peptides for Potential Targeting of Lipoteichoic Acid: An In Silico Assessment.Biomedicines · 2021Article
- Safety and Efficacy of a Phage, kpssk3, in anFrontiers in microbiology · 2021Article
- The Union Is Strength: The Synergic Action of Long Fatty Acids and a Bacteriophage againstMicroorganisms · 2020Article
- An Innovative Approach to ControlMicroorganisms · 2020Article
- Antibiofilm Activity of aMicroorganisms · 2020Article
- Bacteriophages Promote Metabolic Changes in Bacteria Biofilm.Microorganisms · 2020Article
- Local Bacteriophage Delivery for Treatment and Prevention of Bacterial Infections.Frontiers in microbiology · 2020Review
- Advanced Mg, Zn, Sr, Si Multi-Substituted Hydroxyapatites for Bone Regeneration.International journal of nanomedicine · 2020Article
- Plant Dynamic Metabolic Response to Bacteriophage Treatment AfterFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe use of bacteriophages represents a valid alternative to conventional antimicrobial treatments, overcoming the widespread bacterial antibiotic resistance phenomenon. In this work, we evaluated whether biomimetic hydroxyapatite (HA) nanocrystals are able to enhance some properties of bacteriophages. The final goal of this study was to demonstrate that biomimetic HA nanocrystals can be used for bacteriophage delivery in the context of bacterial infections, and contribute - at the same time - to enhance some of the biological properties of the same bacteriophages such as stability, preservation, antimicrobial activity, and so on. MATERIALS AND
methodsPhage isolation and characterization were carried out by using Mitomycin C and following double-layer agar technique. The biomimetic HA water suspension was synthesized in order to obtain nanocrystals with plate-like morphology and nanometric dimensions. The interaction of phages with the HA was investigated by dynamic light scattering and Zeta potential analyses. The cytotoxicity and intracellular killing activities of the phage-HA complex were evaluated in human hepatocellular carcinoma HepG2 cells. The bacterial inhibition capacity of the complex was assessed on chicken minced meat samples infected with
resultsOur data highlighted that the biomimetic HA nanocrystal-bacteriophage complex was more stable and more effective than phages alone in all tested experimental conditions.
conclusionOur results evidenced the important contribution of biomimetic HA nanocrystals: they act as an excellent carrier for bacteriophage delivery and enhance its biological characteristics. This study confirmed the significant role of the mineral HA when it is complexed with biological entities like bacteriophages, as it has been shown for molecules such as lactoferrin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.