ArticleNature biomedical engineering2019
Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain.
Article in Nature biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 122 papers.
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Who cites it
122 citing papers in PubMed.
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Review
- Deep Learning for scaling large-aperture photoacoustic computed tomography : From single fingers to the human hand.Ultrasonics · 2026Article
- Integrated two-photon and photoacoustic microscopy for single-cell neurometabolic imaging.Nature communications · 2026Article
- High-Speed Volumetric Dual-Mode Ultrasound and Photoacoustic Tomography With a Single-Element Detector.IEEE transactions on medical imaging · 2026Article
- Circular-scanning variance delay and sum algorithm for photoacoustic imaging.Biomedical optics express · 2026Article
- Photo-activated ultrasound localization imaging with laser-activated nanodroplets.Communications engineering · 2026Article
- A Hybrid Diffusion Model Enhances Multiparametric 3D Photoacoustic Computed Tomography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Laser Ultrasound Super-Resolution Imaging for Multi-Parametric Non-Invasive Volumetric Characterization of Brain Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cross-regional real-time visualization of systemic physiology and dynamics with 3D panoramic photoacoustic computed tomography (3D-PanoPACT).Nature communications · 2025Article
- Imaging the brain by traversing the skull with light and sound.Nature biomedical engineering · 2025Review
- Sinogram to image: direct reconstruction of photoacoustic tomography image using a hybrid deep learning approach.Biomedical optics express · 2025Article
- Recent advancements in molecular photoacoustic tomography.JPhys photonics · 2025Review
- Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography.Light, science & applications · 2025Article
- Hybrid transformer-CNN network-driven optical-scanning undersampling for photoacoustic remote sensing microscopy.Photoacoustics · 2025Article
- Multimodal fluorescence-optoacousticPhotoacoustics · 2025Article
- Ultrafast filtered back-projection for photoacoustic computed tomography.Biomedical optics express · 2025Article
- Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes.Journal of functional biomaterials · 2025Review
- Spiral volumetric optoacoustic and ultrasound (SVOPUS) tomography of mice.Photoacoustics · 2024Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
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- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
Efforts to scale neuroimaging towards the direct visualization of mammalian brain-wide neuronal activity have faced major challenges. Although high-resolution optical imaging of the whole brain in small animals has been achieved ex vivo, the real-time and direct monitoring of large-scale neuronal activity remains difficult, owing to the performance gap between localized, largely invasive, optical microscopy of rapid, cellular-resolved neuronal activity and whole-brain macroscopy of slow haemodynamics and metabolism. Here, we demonstrate both ex vivo and non-invasive in vivo functional optoacoustic (OA) neuroimaging of mice expressing the genetically encoded calcium indicator GCaMP6f. The approach offers rapid, high-resolution three-dimensional snapshots of whole-brain neuronal activity maps using single OA excitations, and of stimulus-evoked slow haemodynamics and fast calcium activity in the presence of strong haemoglobin background absorption. By providing direct neuroimaging at depths and spatiotemporal resolutions superior to optical fluorescence imaging, functional OA neuroimaging bridges the gap between functional microscopy and whole-brain macroscopy.
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