Evidence map›Paper›PMID 30992502›Full record

ArticleScientific reports2019

A whole-body FDG PET/MR atlas for multiparametric voxel-based analysis.

Therese Sjöholm, Simon Ekström, Robin Strand, Håkan Ahlström, Lars Lind, Filip Malmberg, Joel Kullberg

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Mapping the knowledge landscape of the PET/MR domain: a multidimensional bibliometric analysis.European journal of nuclear medicine and molecular imaging · 2025
    Review
  3. Article
  4. A whole-body diffusion MRI normal atlas: development, evaluation and initial use.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Therese SjöholmDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden. therese.sjoholm@surgsci.uu.se.ORCID http://orcid.org/0000-0003-3072-749X
Simon EkströmDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Robin StrandDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-7764-1787
Håkan AhlströmDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Filip MalmbergDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Joel KullbergDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantitative multiparametric imaging is a potential key application for Positron Emission Tomography/Magnetic Resonance (PET/MR) hybrid imaging. To enable objective and automatic voxel-based multiparametric analysis in whole-body applications, the purpose of this study was to develop a multimodality whole-body atlas of functional 18F-fluorodeoxyglucose (FDG) PET and anatomical fat-water MR data of adults. Image registration was used to transform PET/MR images of healthy control subjects into male and female reference spaces, producing a fat-water MR, local tissue volume and FDG PET whole-body normal atlas consisting of 12 male (66.6 ± 6.3 years) and 15 female (69.5 ± 3.6 years) subjects. Manual segmentations of tissues and organs in the male and female reference spaces confirmed that the atlas contained adequate physiological and anatomical values. The atlas was applied in two anomaly detection tasks as proof of concept. The first task automatically detected anomalies in two subjects with suspected malignant disease using FDG data. The second task successfully detected abnormal liver fat infiltration in one subject using fat fraction data.

Indexed as

AgedFemaleFluorodeoxyglucose F18HumansMagnetic Resonance ImagingMaleMiddle AgedMultimodal ImagingPositron-Emission TomographyProspective StudiesWhole Body ImagingFluorodeoxyglucose F18

Identifiers

PMID30992502
PMCPMC6467986

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.