Evidence map›Paper›PMID 30992368›Full record

ArticleThe Journal of biological chemistry2019

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca

Luning Yang, Alessandro D Uboldi, Simona Seizova, Mary-Louise Wilde, Michael J Coffey, Nicholas J Katris, Yoshiki Yamaryo-Botté, Martina Kocan, Ross A D Bathgate, Rebecca J Stewart and 4 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  6. Orthologs ofMicrobiology spectrum · 2024
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  9. Changes in KInternational journal of molecular sciences · 2023
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  18. Dominique Soldati-Favre: BringingFrontiers in cellular and infection microbiology · 2022
    Article
  19. eLife · 2021
    Article
  20. Calcium signaling in intracellular protist parasites.Current opinion in microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Luning YangFrom the The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia.ORCID 0000-0001-7863-6605
Alessandro D UboldiFrom the The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia.
Simona SeizovaFrom the The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia.
Mary-Louise WildeFrom the The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia.
Michael J CoffeyFrom the The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia.ORCID 0000-0002-8025-4558
Nicholas J KatrisApicoLipid Team, Institute of Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209, Grenoble, France.
Yoshiki Yamaryo-BottéApicoLipid Team, Institute of Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209, Grenoble, France.
Martina KocanFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia.
Ross A D BathgateFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia.
Rebecca J StewartFrom the The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia.
Malcolm J McConvilleDepartment of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3052, Australia, and.ORCID 0000-0002-7107-7887
Philip E ThompsonMonash Institute of Pharmaceutical Science, Monash University, Parkville, Victoria 3052, Australia.
Cyrille Y BottéApicoLipid Team, Institute of Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209, Grenoble, France.
Christopher J TonkinFrom the The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia, tonkin@wehi.edu.au.ORCID 0000-0002-7036-6222
The University of Melbourne · AUCentre National de la Recherche Scientifique · FRMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protozoan parasites of the phylum Apicomplexa actively move through tissue to initiate and perpetuate infection. The regulation of parasite motility relies on cyclic nucleotide-dependent kinases, but how these kinases are activated remains unknown. Here, using an array of biochemical and cell biology approaches, we show that the apicomplexan parasite

Indexed as

Calcium SignalingAdenosine TriphosphatasesCalciumCalcium IonophoresCyclic GMPCytosolGuanylate CyclaseHydrogen-Ion ConcentrationOligonucleotides, AntisensePotassiumProtozoan ProteinsPyrazolesPyrimidinonesToxoplasma5-benzyl-3-isopropyl-1H-pyrazolo(4,3-d)pyrimidin-7(6H)-oneAdenosine TriphosphatasesCalciumCalcium IonophoresCyclic GMPGuanylate CyclaseOligonucleotides, AntisensePotassiumProtozoan ProteinsPyrazolesPyrimidinonescalciumcell motilitycyclic GMP (cGMP)cyclic nucleotideToxoplasma gondii

Identifiers

PMID30992368
PMCPMC6552420
OpenAlexW2939630849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.