Evidence map›Paper›PMID 30992306›Full record

Trial reportDrug metabolism and disposition: the biological fate of chemicals2019

Pharmacokinetic Interaction between Naloxone and Naltrexone Following Intranasal Administration to Healthy Subjects.

Philip Krieter, C Nora Chiang, Shwe Gyaw, Phil Skolnick, Rebekah Snyder

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug metabolism and disposition: the biological fate of chemicals, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Respiratory Depression Associated with Opioids: A Narrative Review.Current treatment options in oncology · 2024
    Review
  3. Review
  4. Review
  5. Developmental Considerations for the Use of Naltrexone in Children and Adolescents.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Philip KrieterNational Institutes of Health, National Institute on Drug Abuse, Bethesda, Maryland (P.K., C.N.C., S.G., P.S.); and Sekisui XenoTech, LLC, Kansas City, Kansas (R.S.) philip.krieter@nih.gov.
C Nora ChiangNational Institutes of Health, National Institute on Drug Abuse, Bethesda, Maryland (P.K., C.N.C., S.G., P.S.); and Sekisui XenoTech, LLC, Kansas City, Kansas (R.S.).
Shwe GyawNational Institutes of Health, National Institute on Drug Abuse, Bethesda, Maryland (P.K., C.N.C., S.G., P.S.); and Sekisui XenoTech, LLC, Kansas City, Kansas (R.S.).
Phil SkolnickNational Institutes of Health, National Institute on Drug Abuse, Bethesda, Maryland (P.K., C.N.C., S.G., P.S.); and Sekisui XenoTech, LLC, Kansas City, Kansas (R.S.).
Rebekah SnyderNational Institutes of Health, National Institute on Drug Abuse, Bethesda, Maryland (P.K., C.N.C., S.G., P.S.); and Sekisui XenoTech, LLC, Kansas City, Kansas (R.S.).
National Institutes of Health · USSekisui XenoTech (United States) · USNational Institute on Drug Abuse · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Naloxone (17-allyl-4,5

Indexed as

Administration, IntranasalAdolescentAdultCross-Over StudiesDouble-Blind MethodDrug InteractionsFemaleHumansMaleMiddle AgedNaloxoneNaltrexoneNarcotic AntagonistsYoung AdultNaloxoneNaltrexoneNarcotic Antagonists

Identifiers

PMID30992306
PMCPMC6548978
OpenAlexW2939623936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.