Trial reportAnnals of the rheumatic diseases2019
Two weeks versus four weeks of antibiotic therapy after surgical drainage for native joint bacterial arthritis: a prospective, randomised, non-inferiority trial.
Trial report in Annals of the rheumatic diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03615781 (Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Antibiotic duration in native and periprosthetic joint infections : a systematic review and meta-analysis of randomized controlled trials.Bone & joint open · 2026Pooled it
- Oral vs Intravenous Antibiotics for Fracture-Related Infections: The POvIV Randomized Clinical Trial.JAMA surgery · 2025Trial
- Comparing Clinical, Microbiological, and Genetic Definitions of Relapse in Patients With Subsequent Episodes of Methicillin-resistant Staphylococcus aureus Bone and Joint Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Bone and Joint Infections in Tropical Settings: High Prevalence of Gram-Negative Bacilli and Implications for Empirical Therapy.Open forum infectious diseases · 2026Article
- Septic arthritis and prosthetic joint infections: microbial spectrum and evolving resistance patterns.Journal of bone and joint infection · 2026Article
- Disseminated meningococcal infection presenting with constrictive pericarditis and bilateral septic arthritis without meningitis: A case report.SAGE open medical case reports · 2026Article
- Ten-Year Experience with Native Joint Septic Arthritis: A Retrospective Cohort Study from a Tertiary Center.Journal of clinical medicine · 2025Article
- Article
- Antibiotic duration for common bacterial infections-a systematic review.JAC-antimicrobial resistance · 2025Review
- The importance of antibiotic treatment duration in antimicrobial resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Review
- Native Joint Septic Arthritis.Antibiotics (Basel, Switzerland) · 2024Review
- Variation in North American Infectious Disease Specialists' Practice Regarding Oral and Suppressive Antibiotics for Adult Osteoarticular Infections: Results of an Emerging Infections Network (EIN) Survey.Open forum infectious diseases · 2024Article
- Early Intervention in Septic Arthritis of the Hand, Optimizing Patient Outcomes in Hand Infections-A Five-Year Retrospective Study.Medicina (Kaunas, Lithuania) · 2024Article
- Article
- Administering Antibiotics for Less Than Four Weeks Increases the Risk of Relapse in Culture-Positive Septic Arthritis of Native Joints.Journal of clinical medicine · 2023Article
- Arthroscopic Treatment of Septic Arthritis of the Ankle Caused by Group B Streptococcus: A Case Report.The American journal of case reports · 2023Article
- Article
- Can the Future of ID Escape the Inertial Dogma of Its Past? The Exemplars of Shorter Is Better and Oral Is the New IV.Open forum infectious diseases · 2023Article
- An update on recent progress of the epidemiology, etiology, diagnosis, and treatment of acute septic arthritis: a review.Frontiers in cellular and infection microbiology · 2023Review
- Septic arthritis of the hand: From etiopathogenesis to surgical treatment.World journal of orthopedics · 2022Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe optimal duration of postsurgical antibiotic therapy for adult native joint bacterial arthritis remains unknown.
methodsWe conducted a prospective, unblinded, randomised, non-inferiority study comparing either 2 or 4 weeks of antibiotic therapy after surgical drainage of native joint bacterial arthritis in adults. Excluded were implant-related infections, episodes without surgical lavage and episodes with a follow-up of less than 2 months.
resultsWe enrolled 154 cases: 77 in the 4-week arm and 77 in the 2-week arm. Median length of intravenous antibiotic treatment was 1 and 2 days, respectively. The median number of surgical lavages was 1 in both arms. Recurrence of infection was noted in three patients (2%): 1 in the 2-week arm (99% cure rate) and 2 in the 4-week arm (97% cure rate). There was no difference in the number of adverse events or sequelae between the study arms. Of the overall 154 arthritis cases, 99 concerned the hand and wrist, for which an additional subgroup analysis was performed. In this per-protocol subanalysis, we noted three recurrences: one in the 2-week arm (97 % cure); two in the 4-week arm (96 % cure) and witnessed sequelae in 50% in the 2-week arm versus 55% in the 4-week arm, of which five (13%) and six (13%) needed further interventions.
conclusionsAfter initial surgical lavage for septic arthritis, 2 weeks of targeted antibiotic therapy is not inferior to 4 weeks regarding cure rate, adverse events or sequelae and leads to a significantly shorter hospital stay, at least for hand and wrist arthritis. TRIAL REGISTRATION NUMBER: NCT03615781.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.