Evidence map›Paper›PMID 30992277›Full record

ArticleDevelopment (Cambridge, England)2019

Activation of butterfly eyespots by Distal-less is consistent with a reaction-diffusion process.

Heidi Connahs, Sham Tlili, Jelle van Creij, Tricia Y J Loo, Tirtha Das Banerjee, Timothy E Saunders, Antónia Monteiro

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Whole genome analysis of toxic Papilionidae butterflies utilizing aristolochic acid, Pachliopta aristolochiae, and Byasa alcinous.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
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  8. eLife · 2024
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  19. Butterfly eyespots evolved via cooption of an ancestral gene-regulatory network that also patterns antennae, legs, and wings.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heidi ConnahsDepartment of Biological Sciences, National University of Singapore, Singapore 117558.ORCID 0000-0002-6615-5668
Sham TliliMechanobiology Institute, National University of Singapore, Singapore 117411.ORCID 0000-0001-6018-9923
Jelle van CreijDepartment of Biological Sciences, National University of Singapore, Singapore 117558.
Tricia Y J LooDepartment of Biological Sciences, National University of Singapore, Singapore 117558.
Tirtha Das BanerjeeDepartment of Biological Sciences, National University of Singapore, Singapore 117558.
Timothy E SaundersDepartment of Biological Sciences, National University of Singapore, Singapore 117558.ORCID 0000-0001-5755-0060
Antónia MonteiroDepartment of Biological Sciences, National University of Singapore, Singapore 117558.ORCID 0000-0001-9696-459X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eyespots on the wings of nymphalid butterflies represent colorful examples of pattern formation, yet the developmental origins and mechanisms underlying eyespot center differentiation are still poorly understood. Using CRISPR-Cas9 we re-examine the function of Distal-less (Dll) as an activator or repressor of eyespots, a topic that remains controversial. We show that the phenotypic outcome of CRISPR mutations depends upon which specific exon is targeted. In

Indexed as

AnimalsButterfliesClustered Regularly Interspaced Short Palindromic RepeatsExonsGene Expression Regulation, DevelopmentalInsect ProteinsMutationInsect ProteinsButterfly eyespotsCRISPR-Cas9Distal-lessGray–Scott reaction-diffusion modelMorphogens

Identifiers

PMID30992277
PMCPMC6526720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.