Evidence map›Paper›PMID 30992267›Full record

ArticleBlood2019

Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background.

Mianmian Yin, Yang Jo Chung, R Coleman Lindsley, Robert L Walker, Yuelin J Zhu, Benjamin L Ebert, Paul S Meltzer, Peter D Aplan

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cancers · 2025
    Article
  5. Structure, function, and pathology of PHF23.Frontiers in cell and developmental biology · 2025
    Review
  6. Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  9. Review
  10. Review
  11. Review
  12. Ontogeny of human B1 cells.International journal of hematology · 2020
    Review
  13. Article
  14. Multi-LineageFrontiers in oncology · 2020
    Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Mianmian YinGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and.
Yang Jo ChungGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and.
R Coleman LindsleyDepartment of Pathology, Brigham and Women's Hospital, and.
Robert L WalkerGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and.
Yuelin J ZhuGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and.
Benjamin L EbertDepartment of Pathology, Brigham and Women's Hospital, and.
Paul S MeltzerGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and.
Peter D AplanGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; and.
National Cancer Institute · USNational Institutes of Health · USCenter for Cancer Research · USDana-Farber Cancer Institute · USHarvard University · US

Funding

Collaborative Pathways that Lead to LeukemiaZIABC010982 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APLAN, PETER · 2009 to 2025
$8.7M
Activation of Proto-Oncogenes by Chromosomal TranslocationZIASC010378 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI APLAN, PETER · 2009 to 2025
$8.4M
Pre-clinical Studies of Therapy for Myelodysplastic SyndromeZIABC010983 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APLAN, PETER · 2009 to 2025
$8.2M
Pre-clinical Studies of Therapy for Myelodysplastic SyndromeZ01BC010983 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APLAN, PETER · 2008 to 2008
$344k
Intramural NIH HHS Z01 BC010983Intramural NIH HHS ZIA SC010378NCI NIH HHS ZIA BC010983NCI NIH HHS ZIA SC010378
6 · The paper itself

Abstract

Approximately 10% of

Indexed as

AnimalsB-Lymphocyte SubsetsFrameshift MutationJanus Kinase InhibitorsJanus KinasesMiceMice, TransgenicNuclear Pore Complex ProteinsOncogene Proteins, FusionPrecursor Cell Lymphoblastic Leukemia-LymphomaPrecursor Cells, B-LymphoidRepressor ProteinsBcor protein, mouseJanus Kinase InhibitorsJanus Kinasesnuclear pore complex protein 98Nuclear Pore Complex ProteinsOncogene Proteins, FusionRepressor Proteins

Identifiers

PMID30992267
PMCPMC6566592
OpenAlexW2939168355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.