ArticleCritical care (London, England)2019
Heterogeneity of regional inflection points from pressure-volume curves assessed by electrical impedance tomography.
Article in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02907840 (Prediction of Response to Recruitment Maneuvers in Patients With Acute Respiratory Failure), which is not on this map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prediction of Response to Recruitment Maneuvers in Patients With Acute Respiratory Failure
Who cites it
30 citing papers in PubMed.
- Distribution of airway pressure opening in the lungs measured with electrical impedance tomography (POET): a prospective physiological study.Critical care (London, England) · 2025Trial
- PEEP and alveolar recruitment after 60 years of acute respiratory distress syndrome.Intensive care medicine · 2026Review
- Detecting regional overdistention during mechanical ventilation using 4-dimensional computed tomography.Scientific reports · 2026Article
- Impact of EIT-based regional ventilation distribution on outcomes in different types of critical illness: a retrospective cohort study.Biomedical engineering online · 2026Article
- Personalized positive-end expiratory pressure using electrical impedance tomography in ARDS patients: a systematic review and meta-analysis.Annals of intensive care · 2026Review
- Airway opening pressure in mechanically ventilated patients: regional distribution and impact of body position.Critical care (London, England) · 2025Article
- Real-time stress and strain monitoring at the bedside: new frontiers in mechanical ventilation.Frontiers in medicine · 2025Review
- Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions.Critical care (London, England) · 2024Review
- Inter-lung asymmetrical airway closure cause insufflation delay between lungs in acute hypoxemic respiratory failure.Annals of intensive care · 2024Article
- The Impact of PEEP on Ventilation Distribution in ARDS.Respiratory care · 2024Article
- Decades Under the Influence: Shifting the PEEP Paradigm in ARDS.Respiratory care · 2024Article
- Article
- Correlation between normally aerated lung and respiratory system compliance at clinical high positive end-expiratory pressure in patients with COVID-19.Scientific reports · 2024Article
- Functional Phenotyping: A New Role for Electrical Impedance Tomography.American journal of respiratory and critical care medicine · 2024Article
- Prone Positioning and Molecular Biomarkers in COVID and Non-COVID ARDS: A Narrative Review.Journal of clinical medicine · 2024Review
- Respiratory Mechanics: Revisiting the Appraisement of Lung Recruitment.Respiratory care · 2023Review
- Clinical Features and Outcomes of Acute Kidney Injury in Critically Ill COVID-19 Patients: A Retrospective Observational Study.Journal of clinical medicine · 2023Article
- Long-term dyspnea, regional ventilation distribution and peripheral lung function in COVID-19 survivors: a 1 year follow up study.BMC pulmonary medicine · 2022Article
- Prone positioning in ARDS patients supported with VV ECMO, what we should explore?Journal of intensive care · 2022Review
- Expert opinion document: "Electrical impedance tomography: applications from the intensive care unit and beyond".Journal of anesthesia, analgesia and critical care · 2022Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pressure-volume (P-V) curve has been suggested as a bedside tool to set mechanical ventilation; however, it reflects a global behavior of the lung without giving information on the regional mechanical properties. Regional P-V (PVr) curves derived from electrical impedance tomography (EIT) could provide valuable clinical information at bedside, being able to explore the regional mechanics of the lung. In the present study, we hypothesized that regional P-V curves would provide different information from those obtained from global P-V curves, both in terms of upper and lower inflection points. Therefore, we constructed pressure-volume curves for each pixel row from non-dependent to dependent lung regions of patients affected by acute hypoxemic respiratory failure (AHRF) and acute respiratory distress syndrome (ARDS).
methodsWe analyzed slow-inflation P-V maneuvers data from 12 mechanically ventilated patients. During the inflation, the pneumotachograph was used to record flow and airway pressure while the EIT signals were recorded digitally. From each maneuver, global respiratory system P-V curve (PVg) and PVr curves were obtained, each one corresponding to a pixel row within the EIT image. PVg and PVr curves were fitted using a sigmoidal equation, and the upper (UIP) and lower (LIP) inflection points for each curve were mathematically identified; LIP and UIP from PVg were respectively called LIPg and UIPg. From each measurement, the highest regional LIP (LIPr
resultsA significant difference (p < 0.001) was found between LIPr
conclusionsRegional inflection points derived by EIT show high variability reflecting lung heterogeneity. Regional P-V curves obtained by EIT could convey more sensitive information than global lung mechanics on the pressures within which all lung regions express linear compliance.
trial registrationClinicaltrials.gov, NCT02907840 . Registered on 20 September 2016.
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